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Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea

2015-06Journal article Open access
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dc.contributor.authorPereira, Hugo
dc.contributor.authorCustodio, Luisa
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorBruno De Sousa, Carolina
dc.contributor.authorOliveira, Marta
dc.contributor.authorBarreira, Luísa
dc.contributor.authorNeng, Nuno da Rosa
dc.contributor.authorFlorencio Nogueira, Jose Manuel
dc.contributor.authorAlrokayan, Salman A.
dc.contributor.authorMouffouk, Fouzi
dc.contributor.authorAbu-Salah, Khalid M.
dc.contributor.authorBen-Hamadou, Radhouan
dc.contributor.authorVarela, João
dc.date.accessioned2018-12-07T14:53:29Z
dc.date.available2018-12-07T14:53:29Z
dc.date.issued2015-06
dc.description.abstractFour lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules. Methanol extracts were thus prepared from freeze-dried biomass and screened for different biological activities. Nannochloris sp. SBL1 and Desmochloris sp. SBL3 had the highest radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, and the best copper and iron chelating activities. All species had potent butyrylcholinesterase inhibitory activity (>50%) and mildly inhibited tyrosinase. Picochlorum sp. SBL2 and Nannochloris sp. SBL4 extracts significantly reduced the viability of tumoral (HepG2 and HeLa) cells with lower toxicity against the non-tumoral murine stromal (S17) cells. Nannochloris sp. SBL1 significantly reduced the viability of Leishmania infantum down to 62% (250 mu g/mL). Picochlorum sp. SBL2 had the highest total phenolic content, the major phenolic compounds identified being salicylic, coumaric and gallic acids. Neoxanthin, violaxanthin, zeaxanthin, lutein and -carotene were identified in the extracts of all strains, while canthaxanthin was only identified in Picochlorum sp. SBL2. Taken together, these results strongly suggest that the microalgae included in this work could be used as sources of added-value products that could be used to upgrade the final biomass value.
dc.description.sponsorshipNational Science, Technology and Innovation Program of King Abdulaziz Medical City for Science and Technology, Riyadh, Saudi Arabia [NPST, 11-ENE 1719-02]; Foundation for Science and Technology (FCT), Portugal [SFRH/BD/78062/2011]; FCT [IF/00049/2012, SFRH/BPD/86071/2012, Pest-OE/QUI/UI0612/2013]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/md13063531
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/11542
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI Ag
dc.relationMARINE ALGAE EXTRACTS AS A SOURCE OF NATURAL ANTILEISHMANIAL COMPOUNDS
dc.relationDESENVOLVIMENTO E APLICAÇÃO DE METODOLOGIAS ANALÍTICAS INOVADORAS COMO TÉCNICAS NÃO INVASIVAS PARA RASTREIO CLÍNICO E TOXICOLOGIA FORENSE
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimers-disease
dc.subjectTyrosinase inhibitors
dc.subjectAntioxidant activity
dc.subjectPhenolic-Compounds
dc.subjectMedicinal-plants
dc.subjectOxidative stress
dc.subjectHuman health
dc.subjectBiofuels
dc.subjectLeishmaniasis
dc.subjectCarotenoids
dc.titleBiological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARINE ALGAE EXTRACTS AS A SOURCE OF NATURAL ANTILEISHMANIAL COMPOUNDS
oaire.awardTitleDESENVOLVIMENTO E APLICAÇÃO DE METODOLOGIAS ANALÍTICAS INOVADORAS COMO TÉCNICAS NÃO INVASIVAS PARA RASTREIO CLÍNICO E TOXICOLOGIA FORENSE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F78062%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F86071%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FQUI%2FUI0612%2F2013/PT
oaire.citation.endPage3549
oaire.citation.issue6
oaire.citation.startPage3531
oaire.citation.titleMarine Drugs
oaire.citation.volume13
oaire.fundingStream3599-PPCDT
person.familyNamePereira
person.familyNameCustódio
person.familyNameRodrigues
person.familyNameBruno de Sousa
person.familyNameOliveira
person.familyNameBarreira
person.familyNameBen-Hamadou
person.familyNameVarela
person.givenNameHugo
person.givenNameLuísa
person.givenNameMaria João
person.givenNameCarolina
person.givenNameMarta
person.givenNameLuísa
person.givenNameRadhouan
person.givenNameJoão
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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