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Thyroid hormone receptor: a new player in epinephrine-induced larval metamorphosis of the hard-shelled mussel

2020-02Journal article Restricted access
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dc.contributor.authorLi, Yi-Feng
dc.contributor.authorCheng, Yu-Lan
dc.contributor.authorChen, Ke
dc.contributor.authorCheng, Zhi-Yang
dc.contributor.authorZhu, Xin
dc.contributor.authorCardoso, João
dc.contributor.authorLiang, Xiao
dc.contributor.authorZhu, You-Ting
dc.contributor.authorPower, Deborah
dc.contributor.authorYang, Jin-Long
dc.date.accessioned2021-06-24T11:35:59Z
dc.date.available2021-06-24T11:35:59Z
dc.date.issued2020-02
dc.description.abstractMany marine invertebrate larvae undergo a dramatic morphological and physiological transition from a planktonic larva to a benthic juvenile. The mechanisms of this metamorphosis in bivalves are mainly unknown. The recent identification in bivalves of a thyroid hormone receptor (TR) gene raises the possibility that as occurs in vertebrate metamorphosis, TRs regulate this developmental process. An evolutionary study of TR receptors revealed they are ubiquitous in the molluscs. Knock-down of the TR gene in pediveliger larvae of the hard-shelled mussel, Mytilus coruscus (Mc), using electroporation of siRNA significantly (p < 0.01) reduced TR gene expression. TR gene knock-down decreased pediveliger larval metamorphosis by 54% and was associated with a significant (p < 0.01) reduction in viability compared to control larvae. The TR in the hard-shelled mussel appears to be an essential regulatory factor for the successful epinephrine-induced metamorphosis of the pediveliger larvae to post-larvae. It is hypothesised that the knock-down of TR by siRNA transfection affects the "competence" of pediveliger larvae for the metamorphic transition by reducing their ability to respond to the inducer. The involvement of TR in the epinephrine-induced metamorphosis of a mollusc, the hard-shelled mussel, suggests the role of TR in this process probably emerged early during evolution.
dc.description.sponsorshipShanghai Sailing Program [18YF1410000]
dc.description.sponsorshipNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31802321, 41606147]
dc.description.sponsorshipspecial fund for science and technology development of Shanghai Ocean University [A2-0203-00-100230]
dc.description.sponsorshipPortuguese National funds from the Foundation for Science and Technology, Portugal (FCT) [UID/Multi/04326/2019]
dc.description.sponsorshipoperational programmes CRESC Algarve 2020, Portugal
dc.description.sponsorshipCOMPETE 2020, Portugal through project EMBRC.PT [ALG-01-0145-FEDER-022121]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.ygcen.2019.113347
dc.identifier.issn0016-6480
dc.identifier.urihttp://hdl.handle.net/10400.1/16594
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre of Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectElectroporation
dc.subjectHard-shelled mussel
dc.subjectLarval metamorphosis
dc.subjectsiRNA
dc.subjectThyroid hormone receptor
dc.subjectTransfection
dc.titleThyroid hormone receptor: a new player in epinephrine-induced larval metamorphosis of the hard-shelled mussel
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2019/PT
oaire.citation.startPage113347
oaire.citation.titleGeneral and Comparative Endocrinology
oaire.citation.volume287
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
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