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Olfactory specialization in the senegalese sole (Solea senegalensis): CO2 acidified water triggers nostril-specific immune processes

2025-04Artigo científico Acesso aberto
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datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorCosta, Rita
dc.contributor.authorHubbard, Peter
dc.contributor.authorManchado, Manuel
dc.contributor.authorPower, Deborah Mary
dc.contributor.authorVelez, Zélia
dc.date.accessioned2026-04-17T12:08:25Z
dc.date.available2026-04-17T12:08:25Z
dc.date.issued2025-04
dc.description.abstractIncreased carbon dioxide (CO2) in the ocean is changing seawater chemistry. Behavioural alterations in CO2 exposed fish have been linked to changes in the central nervous system (CNS). However, we hypothesise that receptor cells in direct contact with the environment are more susceptible to changes in water chemistry than the CNS. Electrophysiology, histology, and transcriptomics were used to explore the effect of exposure to CO2 acidified water on the olfactory epithelium (OE) of the Senegalese sole (Solea senegalensis). The upper and lower OE of this flatfish detect different odorants and are in contact with different environments. Acute exposure to acidified water decreased olfactory sensitivity more in the upper than in the lower OE. After chronic exposure to high CO2 there were no histological changes in the upper OE; however, in the lower OE, there was a massive infiltration of melanomacrophage (MMC) and tissue disorganization. In addition, in the upper OE, differential expressed gene transcripts (DETs) were related to inflammation and innate immune processes whereas in the lower OE, DETs were related to the adaptative immune response. Differential regulation of genes related to neurogenesis and plasticity occurred in both epithelia. The effects of ocean acidification in sole OE depends on the nostril; however, the occurrence of an exacerbated immune response, OE remodelling and reduced sensitivity indicate that ocean acidification is likely to have significant and unpredictable consequences for behaviour.eng
dc.description.sponsorshipPTDC/BIABMA/30262/2017; DL57/2016/CP1361/CT0041
dc.identifier.doi10.1016/j.cbpa.2025.111820
dc.identifier.issn1095-6433
dc.identifier.urihttp://hdl.handle.net/10400.1/28708
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCO2
dc.subjectDifferential gene expression
dc.subjectImmunity
dc.subjectOcean acidification
dc.subjectOlfaction
dc.subjectSolea senegalensis
dc.titleOlfactory specialization in the senegalese sole (Solea senegalensis): CO2 acidified water triggers nostril-specific immune processeseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04326/2020
oaire.awardNumberUIDP/04326/2020
oaire.awardNumberLA/P/0101/2020
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issuePart A
oaire.citation.startPage111820
oaire.citation.titleComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
oaire.citation.volume302
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCosta
person.familyNameHubbard
person.familyNamePower
person.familyNameVelez
person.givenNameRita
person.givenNamePeter
person.givenNameDeborah Mary
person.givenNameZélia
person.identifier.ciencia-id8219-DFF3-929F
person.identifier.ciencia-id951F-BA4B-A21F
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id4412-F95B-34A2
person.identifier.orcid0000-0002-6975-7576
person.identifier.orcid0000-0002-3007-4647
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0003-2761-4048
person.identifier.ridO-9136-2018
person.identifier.ridB-2823-2008
person.identifier.ridM-5283-2013
person.identifier.scopus-author-id57097731700
person.identifier.scopus-author-id7005928467
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id16176444400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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