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Maternal thyroid hormones are essential for neural development in Zebrafish

2014-07Journal article Open access
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dc.contributor.authorCampinho, Marco António
dc.contributor.authorSaraiva, João
dc.contributor.authorFlorindo, Claudia
dc.contributor.authorPower, Deborah M.
dc.date.accessioned2018-12-07T14:53:19Z
dc.date.available2018-12-07T14:53:19Z
dc.date.issued2014-07
dc.description.abstractTeleost eggs contain an abundant store of maternal thyroid hormones (THs), and early in zebrafish embryonic development, all the genes necessary for TH signaling are expressed. Nonetheless the function of THs in embryonic development remains elusive. To test the hypothesis that THs are fundamental for zebrafish embryonic development, an monocarboxilic transporter 8 (Mct8) knockdown strategy was deployed to prevent maternal TH uptake. Absence of maternal THs did not affect early specification of the neural epithelia but profoundly modified later dorsal specification of the brain and spinal cord as well as specific neuron differentiation. Maternal THs acted upstream of pax2a, pax7, and pax8 genes but downstream of shha and fgf8a signaling. The lack of inhibitory spinal cord interneurons and increased motoneurons in the mct8 morphants is consistent with their stiff axial body and impaired mobility. The mct8 mutations are associated with X-linked mental retardation in humans, and the cellular and molecular consequences of MCT8 knockdown during embryonic development in zebrafish provides new insight into the potential role of THs in this condition.
dc.description.sponsorshipPortuguese Science Foundation (FCT) [PTDC/MAR/115005/2009]; FCT [SFRH/BPD/66808/2009, SFRH/BPD/67008/2009, Pest-OE/EQB/LA0023/2013]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1210/me.2014-1032
dc.identifier.issn0888-8809
dc.identifier.urihttp://hdl.handle.net/10400.1/11457
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEndocrine Society
dc.relationMapping gene networks in asymmetric head development during flatfish metamorphosis.
dc.relationMOLECULAR AND CELLULAR EFFECTS OF IOXINIL AND DIETHYLSTILBESTROL ON ZEBRAFISH THYROCYTE DEVELOPMENT AND ADULT HOMEOSTASIS
dc.relationOLFACTO E REPRODUÇÃO: A INFLUÊNCIA DA COMUNICAÇÃO QUÍMICA NA PUBERDADE EM PEIXES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEmbryonic-development
dc.subjectReceptor Alpha-1
dc.subjectBrain-development
dc.subjectTarget genes
dc.subjectDanio-Rerio
dc.subjectIodothyronine deiodinases
dc.subjectTransgenic Zebrafish
dc.subjectLarval development
dc.subjectMouse cerebellum
dc.subjectSpinal-cord
dc.titleMaternal thyroid hormones are essential for neural development in Zebrafish
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMapping gene networks in asymmetric head development during flatfish metamorphosis.
oaire.awardTitleMOLECULAR AND CELLULAR EFFECTS OF IOXINIL AND DIETHYLSTILBESTROL ON ZEBRAFISH THYROCYTE DEVELOPMENT AND ADULT HOMEOSTASIS
oaire.awardTitleOLFACTO E REPRODUÇÃO: A INFLUÊNCIA DA COMUNICAÇÃO QUÍMICA NA PUBERDADE EM PEIXES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR%2F115005%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F66808%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F67008%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.citation.endPage1149
oaire.citation.issue7
oaire.citation.startPage1136
oaire.citation.titleCurrent topics in molecular endocrinology
oaire.citation.volume28
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameCampinho
person.familyNameSaraiva
person.familyNameFlorindo
person.familyNamePower
person.givenNameMarco António
person.givenNameJoão
person.givenNameClaudia
person.givenNameDeborah Mary
person.identifier292979
person.identifier.ciencia-id0E18-2560-6EC1
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person.identifier.ciencia-id7812-FEB4-622A
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0002-8891-8881
person.identifier.orcid0000-0003-4549-2179
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
person.identifier.ridM-6167-2013
person.identifier.scopus-author-id8938999600
person.identifier.scopus-author-id26325116400
person.identifier.scopus-author-id26531090300
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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