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Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study

dc.contributor.authorSilva, Ana P.
dc.contributor.authorViegas, Carla
dc.contributor.authorMendes, Filipa
dc.contributor.authorMacedo, Ana
dc.contributor.authorGuilherme, Patrícia
dc.contributor.authorTavares, Nelson
dc.contributor.authorDias, Carolina
dc.contributor.authorRato, Fátima
dc.contributor.authorSantos, Nélio
dc.contributor.authorFaísca, Marília
dc.contributor.authorAlmeida, Edgar de
dc.contributor.authorNeves, Pedro Leão
dc.contributor.authorSimes, Dina
dc.date.accessioned2020-05-15T16:37:12Z
dc.date.available2020-05-15T16:37:12Z
dc.date.issued2020
dc.description.abstractVascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies. Gla-rich protein (GRP) is a cardiovascular calcification inhibitor, whose clinical utility is here highlighted. The present study explores, for the first time, correlations between levels of GRP in serum with CKD developmental stage, mineral metabolism markers, VC and pulse pressure (PP), in a cohort of 80 diabetic patients with mild to moderate CKD (stages 2-4). Spearman's correlation analysis revealed a positive association of GRP serum levels with estimated glomerular filtration rate (eGFR) and α-Klotho, while a negative correlation with phosphate (P), fibroblast growth factor 23 (FGF-23), vascular calcification score (VCS), PP, calcium (x) phosphate (CaxP) and interleukin 6 (IL-6). Serum GRP levels were found to progressively decrease from stage 2 to stage 4 CKD. Multivariate analysis identified low levels of eGFR and GRP, and high levels of FGF-23 associated with both the VCS and PP. These results indicate an association between GRP, renal dysfunction and CKD-mineral and bone disorder. The relationship between low levels of GRP and vascular calcifications suggests a future, potential utility for GRP as an early marker of vascular damage in CKD.pt_PT
dc.description.sponsorshipPortuguese Society of Nephrology (SPN) ; Portuguese national funds from FCT-Foundation for Science and Technology through the transitional provision DL57/2016/CP1361/CT0006 UIDB/04326/2020pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/jcm9030635pt_PT
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.1/13896
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChronic kidney diseasept_PT
dc.subjectVascular calcification inhibitorspt_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectGla-rich proteinpt_PT
dc.subjectCardiovascular calcificationpt_PT
dc.subjectCardiovascular risk assessmentpt_PT
dc.titleGla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage635pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume9pt_PT
person.familyNameViegas
person.familyNameMendes
person.familyNameMacedo
person.familyNameNeves
person.familyNameSimes
person.givenNameCarla
person.givenNameFilipa
person.givenNameAna
person.givenNamePedro Leão
person.givenNameDina
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-id8414-F029-8182
person.identifier.ciencia-id1014-3EA2-C680
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-0329-8805
person.identifier.orcid0000-0002-6978-8989
person.identifier.orcid0000-0002-8463-0768
person.identifier.orcid0000-0002-5145-4753
person.identifier.ridN-6695-2014
person.identifier.ridL-9912-2018
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id7003907170
person.identifier.scopus-author-id7201884723
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication33984b3c-ffac-477a-896a-ddbf7aced4e3
relation.isAuthorOfPublication871b65e7-2325-4468-a518-070543f80346
relation.isAuthorOfPublication8e798bcb-5052-47b0-a050-32f40328cc1a
relation.isAuthorOfPublication788c02e9-1087-4e30-8a34-5379261fc739
relation.isAuthorOfPublication31bac96d-1d01-4b8f-8f2b-9da4be31ea41
relation.isAuthorOfPublication.latestForDiscovery871b65e7-2325-4468-a518-070543f80346

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