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Highlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

2019Journal article Open access
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dc.contributor.authorCui, Bing
dc.contributor.authorEyers, Patrick A.
dc.contributor.authorDobens, Leonard L.
dc.contributor.authorTan, Nguan Soon
dc.contributor.authorMace, Peter D.
dc.contributor.authorLink, Wolfgang
dc.contributor.authorKiss-Toth, Endre
dc.contributor.authorKeeshan, Karen
dc.contributor.authorNakamura, Takuro
dc.contributor.authorPear, Warren S.
dc.contributor.authorFeseha, Yodit
dc.contributor.authorJohnston, Jessica
dc.contributor.authorCarracedo, Arkatiz
dc.contributor.authorScheideler, Marcel
dc.contributor.authorllyas, Zabran
dc.contributor.authorBauer, Robert C.
dc.contributor.authorErusalimsky, Jorge D.
dc.contributor.authorGrzesik, Dominika
dc.contributor.authorSalamanca-Viloria, Juan
dc.contributor.authorLv, Xiaoxi
dc.contributor.authorJin, Yishi
dc.contributor.authorLi, Ke
dc.contributor.authorVelasco, Guillermo
dc.contributor.authorShang, Shuang
dc.contributor.authorLizcano, Jose M.
dc.contributor.authorZhang, Xiaowei
dc.contributor.authorZhou, Jichao
dc.contributor.authorYu, Jiaojiao
dc.contributor.authorHua, Fang
dc.contributor.authorWang, Feng
dc.contributor.authorLiu, Shanshan
dc.contributor.authorYu, Jinmei
dc.contributor.authorHu, Zhuowei
dc.date.accessioned2019-05-21T14:22:27Z
dc.date.available2019-05-21T14:22:27Z
dc.date.issued2019
dc.description.abstractThe Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Symposium on Tribbles and Diseases held on May 7-9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.pt_PT
dc.description.sponsorshipAgência financiadora / Número do subsídio National Key R&D Program of China (China) 2017YFA0205400 National Natural Science Foundation of China (China) 81530093 81773781 81874316 81503128 81400140 81400286 81703564 81603129 81472717 81673474 Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (China) 2016-12M-1-007 CAMS Central Public-interest Scientific Institution Basic Research Fund (China) 2017PT3104 CAMS Innovation Fund for Medical Sciences (China) 2016-I2M-3-008 201642M-1-008 201642M-1-007 201642M-1-011 201642M-1-010 BBSRC (UK) 1088 1097 NWCR (UK) 1088 1097 NSF (USA) IOS-1456023 NIH (USA) NIH R21 CA197317 Ministry of Education, Singapore (Singapore) MOE2014-T2-1-012 2012-T1-001-036 Health Research Council of New Zealand Rutherford Discovery Fellowship from the New Zealand government Fundacao para a Ciencia e a Tecnologia (FCT) UID/KM/04773/2013 Liga Portuguesa Contra o Cancro NUcleo Regional do Sul (LPCC/NRS, Portugal) FCT 2014 research grant (Portugal) SFRH/BPD/100434/2014 ProRegem grant (Portugal) PD/BD/114258/2016 European Marie Sklodowska Curie ITN Project TRAIN-TRIBBLES Research and Innovation Network (EU) 721532 British Heart Foundation (UK) PG/16/44/32146 Howat Foundation Ltd. (UK) Children with Cancer UK (UK) Bloodwise (UK) Friends of Paul O' Gorman (UK) grants of P-CREATE from Japan Agency for Medical Research and Development NIH (NIAID, USA) Alex' s Lemonade Stand Foundation (USA) Samuel Waxman Cancer Research Foundation (USA) French government (France) ANR-10-IBHU-005 ANR-11-LABX-0016-01 European Marie Sklodowska Curie ITN Project TRAIN-TRIBBLES Research and Innovation Network (UK) 721532 A* Star Institute (UK) University of Sheffield (UK) National Institutes of Health National Heart, Lung, and Blood Institute (USA) R01HL141745 National Institute of Health (USA) NS R01-035546 Spanish Ministry of Economy and Competitiveness (MINECO) (Spain) INNPACTO/IPT-2012-0614-010000 Fondo Europeo de desarrollo Regional (FEDER) (Spain) INNPACTO/IPT-2012-0614-010000 PerkinElmer Innovent Biologics Nantes Metropole (France) Region Pays de la Loire (France) Beijing Natural Science Foundation (China) 7162133pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.apsb.2018.12.007pt_PT
dc.identifier.issn2211-3835
dc.identifier.urihttp://hdl.handle.net/10400.1/12538
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationTribbles Research and Innovation Network
dc.relationEuropean Medicines Research Training Network
dc.relationPortugal Twinning for innovation and excellence in marine science and Earth observation
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTribblespt_PT
dc.subjectImmunologypt_PT
dc.subjectMetabolismpt_PT
dc.subjectCell biologypt_PT
dc.subjectKinase inhibitorpt_PT
dc.subjectTumorigenesispt_PT
dc.subjectMetastasispt_PT
dc.subjectTRIB1pt_PT
dc.subjectTRIB2pt_PT
dc.subjectTRIB3pt_PT
dc.subjectPseudokinasept_PT
dc.subjectInflammationpt_PT
dc.subjectAtomic structurept_PT
dc.subjectProtein quality controlpt_PT
dc.subjectUbiqutinpt_PT
dc.titleHighlights of the 2nd international symposium on tribbles and diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTribbles Research and Innovation Network
oaire.awardTitleEuropean Medicines Research Training Network
oaire.awardTitlePortugal Twinning for innovation and excellence in marine science and Earth observation
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/721532/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/115015/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/810139/EU
oaire.citation.endPage454pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage443pt_PT
oaire.citation.titleActa Pharmaceutica Sinica Bpt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamH2020
oaire.fundingStreamFP7
oaire.fundingStreamH2020
person.familyNameLink
person.givenNameWolfgang
person.identifier803637
person.identifier.ciencia-id6910-952E-242A
person.identifier.orcid0000-0002-3340-5165
person.identifier.scopus-author-id35368713800
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12535e25-d71b-4a7f-9fc9-fff42d47deaf
relation.isAuthorOfPublication.latestForDiscovery12535e25-d71b-4a7f-9fc9-fff42d47deaf
relation.isProjectOfPublication43837991-eb25-4bc1-bb31-a44a6ae93c59
relation.isProjectOfPublicationd4166d9a-9f57-4b62-8c61-d772fee7afb5
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