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Dietary tryptophan plays a role as an anti-inflammatory agent in european seabass (dicentrarchus labrax) juveniles during Chronic Inflammation

2024-04-29Journal article Open access
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dc.contributor.authorAzeredo, Rita
dc.contributor.authorPeixoto, Diogo
dc.contributor.authorPaulo Santos
dc.contributor.authorDuarte, Inês
dc.contributor.authorRicardo, Ana
dc.contributor.authorMachado, Marina
dc.contributor.authorCostas, Benjamín
dc.contributor.authorAragão, Cláudia
dc.date.accessioned2024-09-04T09:26:05Z
dc.date.available2024-09-04T09:26:05Z
dc.date.issued2024-04-29
dc.description.abstractWhere teleost fish are concerned, the effects of a dietary tryptophan surplus are mostly immunosuppressive, making it a potential dietary anti-inflammatory strategy. The goal of the present work was to evaluate the effects of tryptophan dietary supplementation on immune and neuroendocrine responses of the European seabass, Dicentrarchus labrax, undergoing chronic inflammation. Juvenile European seabass were intraperitoneally injected with an inflammatory agent (inflamed group) or a saline solution (control group). Within each group, fish were fed a control and a control-based diet supplemented with tryptophan for 4 weeks. Different tissues were sampled every week for the assessment of immune-related parameters. When tryptophan was provided to fish undergoing inflammation, the gene expression of a macrophage marker increased sooner and remained high until the end of the experiment. The same fish showed a concurrent increase in peripheral monocyte counts. After one week, molecular patterns of anti-inflammatory processes seemed to be favoured by tryptophan. Altogether, results show that a short administration period seems to be critical where tryptophan supplementation is concerned since at later inflammatory stages—and longer feeding periods—fish fed this diet displayed a molecular profile similar to that of fish fed a control diet.eng
dc.description.sponsorshipLA/P/0101/2020; 2022.03248.CEECIND; 2022.03304.CEECIND; UI/BD/150900/2021
dc.identifier.doi10.3390/biology13050309
dc.identifier.issn2079-7737
dc.identifier.urihttp://hdl.handle.net/10400.1/25837
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationUnraveling neuro-endocrine/immune modulatory roles of tryptophan during inflammation
dc.relationMethionine and tryptophan as nutraceutical strategies to improve mucosal immunity and vaccine efficiency in fish
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationThe modulatory role of tryptophan on the neuroendocrine and immune crosstalk
dc.relation.ispartofBiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFunctional ingredient
dc.subjectSerotonergic activity
dc.subjectInnate immunity
dc.subjectInflammation
dc.titleDietary tryptophan plays a role as an anti-inflammatory agent in european seabass (dicentrarchus labrax) juveniles during Chronic Inflammationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUnraveling neuro-endocrine/immune modulatory roles of tryptophan during inflammation
oaire.awardTitleMethionine and tryptophan as nutraceutical strategies to improve mucosal immunity and vaccine efficiency in fish
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleThe modulatory role of tryptophan on the neuroendocrine and immune crosstalk
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FCVT-CVT%2F32349%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020/PTDC%2FCVT-CVT%2F7741%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F150900%2F2021/PT
oaire.citation.issue5
oaire.citation.startPage309
oaire.citation.titleBiology
oaire.citation.volume13
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAragão
person.givenNameCláudia
person.identifier174173
person.identifier.ciencia-idD01E-0726-9F3E
person.identifier.orcid0000-0002-9217-0183
person.identifier.ridK-2310-2012
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