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Dual challenge inside the womb: a case report of concomitant fetal atrio-ventricular block associated with maternal anti-SSA antibodies and fetal tachyarrhythmia diagnosed as Wolff-Parkinson-White syndrome after birth

2024-07-24Journal article Open access
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dc.contributor.authorChícharo, Ana Teodósio
dc.contributor.authorRebelo, Mónica
dc.contributor.authorLopes, Ana Rita
dc.contributor.authorSaavedra, Maria João
dc.contributor.authorParamés, Maria Filipa
dc.contributor.authorAraújo, Ana Rita
dc.contributor.authorMachado, Ana Rita Cruz
dc.contributor.authorPinto, Luísa
dc.contributor.authorCapela, Susana
dc.date.accessioned2024-11-29T13:47:34Z
dc.date.available2024-11-29T13:47:34Z
dc.date.issued2024-07-24
dc.description.abstractFetal autoimmune atrioventricular block (AVB) is a rare but potentially life-threatening condition. It results from the passage of maternal anti-SSA/Ro or Anti SSB/La auto-antibodies into the fetal circulation, leading to inflammation and fibrosis of the AV node and often to irreversible damage. Besides AVB, these antibodies can also cause cardiomyopathies, but there is no evidence linking them to tachyarrhythmias. We present the case of a patient with significant risk factors for fetal AVB: a prior history of hydrops fetalis, high anti-SSA/Ro antibody levels and hypothyroidism. In this case, the use of dexamethasone and intravenous immunoglobulin may have contributed to reversing the first-degree atrioventricular block detected at 19 weeks of gestation. Additionally, at 21 weeks, the fetus developed a tachyarrhythmia that needed treatment with flecainide. Soon after the birth, the newborn underwent ECG Holter and Wolff-Parkinson-White Syndrome (WPWS) was diagnosed. To our knowledge, the coexistence of fetal AVB and WPWS has never been described.eng
dc.identifier.doi10.3389/fimmu.2024.1397103
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10400.1/26370
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relation.hasversionhttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1397103/full
dc.relation.ispartofFrontiers in Immunology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectWolff-Parkinson-White syndrome
dc.subjectAnti-SSA/Ro antibodies
dc.subjectCase report
dc.subjectCongenital heart block
dc.subjectFetal atrio-ventricular block
dc.subjectPregnancy
dc.titleDual challenge inside the womb: a case report of concomitant fetal atrio-ventricular block associated with maternal anti-SSA antibodies and fetal tachyarrhythmia diagnosed as Wolff-Parkinson-White syndrome after birtheng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6
oaire.citation.startPage1
oaire.citation.titleFrontiers in Immunology
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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