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The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish

2007-02-01Journal article Restricted access
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dc.contributor.authorGuerreiro, P. M.
dc.contributor.authorRenfro, J. Larry
dc.contributor.authorPower, Deborah
dc.contributor.authorCanario, Adelino V. M.
dc.date.accessioned2014-05-15T15:05:26Z
dc.date.available2014-05-15T15:05:26Z
dc.date.issued2007-02-01
dc.date.updated2014-05-13T09:28:41Z
dc.description.abstractParathyroid hormone (PTH) and PTH-related protein (PTHrP) are two factors that share amino acid sequence homology and act via a common receptor. In tetrapods, PTH is the main endocrine factor acting in bone and kidney to regulate calcium and phosphate. PTHrP is an essential paracrine developmental factor present in many tissues and is involved in the regulation of ossification, mammary gland development, muscle relaxation, and other functions. Fish apparently lack an equivalent of the parathyroid gland and were long thought to be devoid of PTH. Only in recent years has the existence of PTH-like peptides and their receptors in fish been firmly established. Two forms of PTH, two of PTHrP, and a protein with intermediate characteristics designated PTH-L are encoded by separate genes in teleost fish. Three receptors encoded by separate genes in fish mediate PTH/PTHrP actions, whereas only two receptors have so far been found in terrestrial vertebrates. PTHrP has been more intensively studied than PTH, from lampreys to advanced teleosts. It is expressed in many tissues and is present in high concentration in fish blood. Administration of this peptide alters calcium metabolism and has marked effects on associated gene expression and enzyme activity in vivo and in vitro. This review provides a comprehensive overview of the physiological roles, distribution, and molecular relationships of the piscine PTH-like peptides.por
dc.identifier.citationGuerreiro, P. M.; Renfro, J. L.; Power, D. M.; Canario, A. V. M.The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 292, 2, R679-R696, 2007.por
dc.identifier.doihttp://dx.doi.org/10.1152/ajpregu.00480.2006
dc.identifier.issn0363-6119
dc.identifier.otherAUT: PMG01122; DPO00386; ACA00258
dc.identifier.urihttp://hdl.handle.net/10400.1/3974
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Physiological Societypor
dc.relation.publisherversionhttp://ajpregu.physiology.org/content/292/2/R679por
dc.subjectParathyroid hormone-related proteinpor
dc.subjectPhosphate regulationpor
dc.subjectCalcium regulationpor
dc.subjectMolecular evolutionpor
dc.titleThe parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fishpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageR696por
oaire.citation.startPageR679por
oaire.citation.titleAmerican Journal of Physiology: regulatory, integrative and comparative physiologypor
oaire.citation.volume292por
person.familyNameGuerreiro da Costa Guerreiro
person.familyNamePower
person.familyNameCanario
person.givenNamePedro Miguel
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifierA-2539-2009
person.identifier143624
person.identifier.ciencia-id5C13-965D-3148
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationd0a8a148-98e7-4899-8fb0-0b8afa91e4a4
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscoveryd0a8a148-98e7-4899-8fb0-0b8afa91e4a4

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