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Accumulation and elimination dynamics of the hydroxybenzoate saxitoxin analogues in mussels Mytilus galloprovincialis exposed to the toxic marine Dinoflagellate Gymnodinium catenatum

2018Journal article Open access
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dc.contributor.authorReis Costa, Pedro
dc.contributor.authorBraga, Ana
dc.contributor.authorTurner, Andrew
dc.date.accessioned2019-03-07T12:48:34Z
dc.date.available2019-03-07T12:48:34Z
dc.date.issued2018
dc.description.abstractParalytic shellfish poisoning (PSP) is a severe food-borne illness, caused by the ingestion of seafood containing paralytic shellfish toxins (PST), which are naturally produced by marine dinoflagellates and accumulate in shellfish during algae blooms. Novel PST, designated as hydroxybenzoate analogues (also known as GC toxins), was relatively recently discovered in Gymnodinium catenatum strains worldwide. However, to date, there have been no studies examining their accumulation in shellfish. In this study, mussels (Mytilus galloprovincialis) were exposed to G. catenatum for five days and then exposed to a non-toxic diet for 24 h, to investigate the toxin's accumulation/elimination dynamics. As determined by UHPLC-HILIC-MS/MS, the hydroxybenzoate analogues, GC1 to GC6, comprised 41% of the algae toxin profile and only 9% in mussels. Elimination of GC toxins after 24 h was not evident. This study highlights that a relevant fraction of PST in mussels are not routinely analysed in monitoring programs and that there is a need to better understand the toxicological potential of the hydroxybenzoate analogues, in order to properly address the risk of G. catenatum blooms.pt_PT
dc.description.sponsorshipCentre for Environment, Fisheries and Aquaculture Science - contract code DP402; Fundacao para a Ciencia e a Tecnologia - PD/BD/113484/2015; FCT Investigator; Mar2020 - SNMB-INOV: Innovation for a more competitive shellfish sector, co-financed by the Operational Program Mar 2020, Portugal 2020pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/toxins10110428pt_PT
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10400.1/12402
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPhysiological adaptations and strategies for toxins elimination by sellfish living with harmful blooms
dc.subjectSaxitoxinpt_PT
dc.subjectShellfish metabolismpt_PT
dc.subjectParalytic shellfish poisoningpt_PT
dc.subjectHarmful algal bloomspt_PT
dc.titleAccumulation and elimination dynamics of the hydroxybenzoate saxitoxin analogues in mussels Mytilus galloprovincialis exposed to the toxic marine Dinoflagellate Gymnodinium catenatumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePhysiological adaptations and strategies for toxins elimination by sellfish living with harmful blooms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F113484%2F2015/PT
oaire.citation.issue11pt_PT
oaire.citation.startPage428pt_PT
oaire.citation.titleToxinspt_PT
oaire.citation.volume10pt_PT
person.familyNameReis Costa
person.givenNamePedro
person.identifier600820
person.identifier.ciencia-idC911-9715-E547
person.identifier.orcid0000-0001-6083-470X
person.identifier.ridN-1908-2019
person.identifier.scopus-author-id7201895802
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication24ad7119-d61f-4bdb-a5d5-9bd6e2c37312
relation.isAuthorOfPublication.latestForDiscovery24ad7119-d61f-4bdb-a5d5-9bd6e2c37312
relation.isProjectOfPublication35d155c3-9873-48c4-9f3c-c1eea1a37aeb
relation.isProjectOfPublication.latestForDiscovery35d155c3-9873-48c4-9f3c-c1eea1a37aeb

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