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Gla-Rich protein is associated with vascular calcification, inflammation, and mineral markers in peritoneal dialysis patients

2024-12-06Journal article Open Access
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dc.contributor.authorMARREIROS, CATARINA
dc.contributor.authorViegas, Carla
dc.contributor.authorMalho Guedes, Anabela
dc.contributor.authorSilva, Ana Paula de Andrade
dc.contributor.authorÁguas, Ana Catarina
dc.contributor.authorFaísca, Marília
dc.contributor.authorSchurgers, Leon
dc.contributor.authorSimes, Dina
dc.date.accessioned2025-01-16T14:09:45Z
dc.date.available2025-01-16T14:09:45Z
dc.date.issued2024-12-06
dc.description.abstractVascular calcification (VC) is a crucial risk factor for cardiovascular diseases (CVD), particularly in chronic kidney disease (CKD) populations. However, the specific relationship between VC and end-stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD) remains to be fully understood. The identification of new biomarkers to improve VC diagnosis and monitoring would significantly impact cardiovascular risk management in these high-risk patients. Gla-rich protein (GRP) is a VC inhibitor and an anti-inflammatory agent and thus is a potential VC marker in CKD. Here we explored the potential role of GRP as a marker for CVD and investigated the impact of VC in 101 PD patients. Methods: Circulating total Gla-rich protein (tGRP) was quantified in serum and in 24 h dialysate samples. VC score (VCS) was determined using the Adragão method. Results: Serum tGRP was negatively associated with VCS, serum calcium (Ca), phosphate (P), and high-sensitivity C-reactive protein (hsCRP), while it was positively associated with magnesium (Mg). A total of 35.6% of PD patients presented with extensive calcifications (VCS ≥ 3), and the lowest tGRP serum levels were present in this group (419.4 ± 198.5 pg/mL). tGRP in the 24 h dialysate was also negatively associated with VCS and with serum Ca and P. Moreover, serum Ca, P, and VCS were identified as independent determinants of serum tGRP levels. Conclusions: The association of serum tGRP with VC, mineral, and inflammation markers reinforces its potential use as a novel VC biomarker in CKD patients undergoing PD.eng
dc.description.sponsorshipDL57/2016/CP1361/CT0006; EXPL/BTM-TEC/0990/2021; 072583-NUTRISAFE
dc.identifier.doi10.3390/jcm13237429
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.1/26635
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relation.ispartofJournal of Clinical Medicine
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPeritoneal dialysis
dc.subjectVascular calcification
dc.subjectAdragão score
dc.subjectGla-Rich protein
dc.subjectBiomarker
dc.titleGla-Rich protein is associated with vascular calcification, inflammation, and mineral markers in peritoneal dialysis patientseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.issue23
oaire.citation.startPage7429
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume13
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMARREIROS
person.familyNameViegas
person.familyNameMalho Guedes
person.familyNameSilva
person.familyNameSimes
person.givenNameCATARINA
person.givenNameCarla
person.givenNameAnabela
person.givenNameAna Paula de Andrade
person.givenNameDina
person.identifier.ciencia-idB116-E70E-EB2A
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-9627-908X
person.identifier.orcid0000-0001-5771-2154
person.identifier.orcid0000-0002-5145-4753
person.identifier.ridN-6695-2014
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id37087078200
person.identifier.scopus-author-id7201884723
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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