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Reproductive endocrine disruption in the freshwater catfish, Heteropneustes fossilis, in response to the pesticide ¿-hexachlorocyclohexane

2004Journal article Restricted access
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dc.contributor.authorSingh, Pratap B.
dc.contributor.authorCanario, Adelino V. M.
dc.date.accessioned2014-05-09T14:53:26Z
dc.date.available2014-05-09T14:53:26Z
dc.date.issued2004
dc.date.updated2014-05-09T09:29:01Z
dc.description.abstractBoth male and female freshwater catfish, Heteropneustes fossilis, were exposed to safe (SC; 0.1 and 1.0 mg/L) and sublethal (SL; 10 mg/L) concentrationsof an agricultural pesticide, g-hexachlorocyclohexane (g-HCH) for 4 weeksduring the active pre-spawning (vitellogenic) phase of their annual reproductive cycle. On the last day of exposure, 18 h before killing, fish were treated intramuscularly (i.m.) with [I-14C]acetic acid (74 kBq per fish). After 4 weeks of exposure, we monitored the effects of g-HCH on gonadosomatic index (GSI); on plasma concentrations of gonadotropin (GtH), testostosterone (T), 11-ketotestosterone (11-KT), 17b-estradiol (E2); and on hepatic incorporation of [I-14C]acetic acid into total phospholipids (TP) and the fractions thereof: phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylinositol (PI), and phosphatidylethanolamine (PE). In both the sexes, GSI and plasma GtH were decreased significantly in response to g-HCH exposure. Plasma T and 11-KT in males, and plasma T and E2 in females declined significantly in response to g-HCH exposure. In both the sexes, hepatic incorporation of [I-14C]acetic acid into PS and PI increased significantly, whereas incorporation into TP, PC, and PE was significantly reduced after g-HCH exposure. Our findings demonstrated that g-HCH exposure depressed GSI, plasma GtH, sex steroids, and [I-14C]acetic acid incorporation into hepatic TP, and had very selective and specific effects on various classes of TP, resulting either from the hypothalamo-hypophyseal-gonadal axis or from direct action on hepatic and steroidogenic enzymes during the pre-spawning phase, causing reproductive endocrine disruptions.por
dc.identifier.citationSingh, Pratap B.; Canario, Adelino V.M. Reproductive endocrine disruption in the freshwater catfish, Heteropneustes fossilis, in response to the pesticide ¿-hexachlorocyclohexane, Ecotoxicology and Environmental Safety, 58, 1, 77-83, 2004.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.ecoenv.2003.07.014
dc.identifier.issn0147-6513
dc.identifier.otherAUT: ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3835
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectg-HCHpor
dc.subjectFish reproductionpor
dc.subjectEndocrine disruptionspor
dc.subjectPhospholipidspor
dc.subjectSex steroidspor
dc.subjectGonadotropinpor
dc.titleReproductive endocrine disruption in the freshwater catfish, Heteropneustes fossilis, in response to the pesticide ¿-hexachlorocyclohexanepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage83por
oaire.citation.issue1por
oaire.citation.startPage77por
oaire.citation.titleEcotoxicology and Environmental Safetypor
oaire.citation.volume58por
person.familyNameCanario
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

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