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Response surface methodology (RSM) for optimization of Euphorbia resinifera and Euphorbia officinarum extracts with antioxidant and anti-diabetic activities

2022-10Journal article Open access
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dc.contributor.authorBoutoub, Oumaima
dc.contributor.authorAAZZA, Smail
dc.contributor.authorEL-GUENDOUZ, Soukaina
dc.contributor.authorEl Ghadraoui, Lahsen
dc.contributor.authorMiguel, Maria
dc.date.accessioned2023-02-02T13:42:08Z
dc.date.available2023-02-02T13:42:08Z
dc.date.issued2022-10
dc.description.abstractBackground: Euphorbia is one of the plants most used by herbalists and therapists in Morocco. Objectives: The aerial part of two plant samples (Euphorbia resinifera and Euphorbia officinarum) collected in Morocco was examined for the solvent effect, extraction time, and plant concentration in order to determine the best extraction conditions. Materials and Methods: To achieve this goal, a response surface methodology (RSM) using a full three-level factorial design was used to optimize the conditions for the extraction of antioxidants and a-glucosidase inhibitors. Temperature, time, and plant-to-solvent ratio (PSR) and their linear and quadratic interactions on TPC (total phenol concentration), TFC (total flavonoid concentration), DPPH (2,2-diphenyl-1-picrylhydrazyl) trapping activity, and a-glucosidase inhibiting activities were studied. Results: According to desirability functions, the optimum operating conditions to achieve a higher extraction yield of phenols and higher antioxidant and anti-diabetic activity were found by using extraction during 60 min at 30 degrees C using a PSR of 20 mg/mL, whereas a longer extraction time (270 min) was needed for E. resinifera and a higher extraction temperature (50 degrees C), with a lower PSR (10 mg/mL) for E. officinarum. Conclusion: In order to find the best conditions to extract secondary metabolites with biological activity and application in phytotherapy, the appropriate solvent generally used by populations, water in this case, should be used, but the best extraction conditions have to be found in order to enhance the pharmacological actions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.4103/pm.pm_2_22pt_PT
dc.identifier.eissn0976-4062
dc.identifier.urihttp://hdl.handle.net/10400.1/18990
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Medknow Publicationspt_PT
dc.relationMediterranean Institute for Agriculture, Environment and Development
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecta-glucosidase inhibitory activitypt_PT
dc.subjectFactorial designpt_PT
dc.subjectResponse surface methodologypt_PT
dc.subjectTotal phenolic compoundspt_PT
dc.subjectTotal flavonoidspt_PT
dc.titleResponse surface methodology (RSM) for optimization of Euphorbia resinifera and Euphorbia officinarum extracts with antioxidant and anti-diabetic activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMediterranean Institute for Agriculture, Environment and Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05183%2F2020/PT
oaire.citation.endPage952pt_PT
oaire.citation.issue80pt_PT
oaire.citation.startPage940pt_PT
oaire.citation.titlePharmacognosy Magazinept_PT
oaire.citation.volume18pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBOUTOUB
person.familyNameEl-Guendouz
person.familyNameMiguel
person.givenNameOUMAIMA
person.givenNameSoukaina
person.givenNameMaria da Graça
person.identifierhttps://scholar.google.com/citations?user=CYBI8q8AAAAJ&hl=fr
person.identifier.ciencia-idAD1D-38AE-BA47
person.identifier.ciencia-id3E11-53A1-4D90
person.identifier.ciencia-id6110-6FE7-DF28
person.identifier.orcid0000-0002-3341-9452
person.identifier.orcid0000-0003-2507-4228
person.identifier.scopus-author-id57190122389
person.identifier.scopus-author-id35562054500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication74dd3524-3fc8-455f-a24f-eacdbf065017
relation.isAuthorOfPublicationf6745212-30ad-4c15-af2e-37a2b4f71b1e
relation.isAuthorOfPublication2507350f-9e60-4d4a-a096-53e58d93549c
relation.isAuthorOfPublication.latestForDiscovery74dd3524-3fc8-455f-a24f-eacdbf065017
relation.isProjectOfPublication823bd652-ee6c-4479-91c5-06095bc37e9c
relation.isProjectOfPublication.latestForDiscovery823bd652-ee6c-4479-91c5-06095bc37e9c

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