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Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.

2026Journal article Open access
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dc.contributor.authorSimao, Sonia
dc.contributor.authorFilipa Santos, Daniela
dc.contributor.authorTeixeira, Mariana
dc.contributor.authorAgostinho, Rafaela R
dc.contributor.authorRodrigues, Joana
dc.contributor.authorVitorino, Marta
dc.contributor.authorAraújo, Inês M
dc.date.accessioned2025-12-30T18:53:39Z
dc.date.available2025-12-30T18:53:39Z
dc.date.issued2026
dc.description.abstractAlzheimer's disease and Parkinson's disease are the two most prevalent neurodegenerative disorders worldwide, both characterized by progressive neuronal loss. Despite distinct pathophysiological features, they share cellular dysfunctions such as abnormal protein aggregation, oxidative stress, and neuroinflammation, research into which might be beneficial for developing novel therapeutic strategies that could tackle both conditions. This review highlights the emerging role of the gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide as modulators of adult neurogenesis and neuroprotection in Alzheimer's disease and Parkinson's disease. We have gathered recent evidence demonstrating that these endogenous gases exert anti-inflammatory, antioxidant, and anti-apoptotic effects, and, critically, promote neurogenesis - suggesting a dual neuroprotective and neuroregenerative therapeutic potential. The unique physicochemical features of these gasotransmitters, including their ability to cross the blood-brain barrier and diffuse rapidly throughout the neural tissue, further support their suitability as candidates for innovative neuroregenerative treatments. While clinical translation remains challenging, harnessing the neurogenic and neuroprotective actions of these gasotransmitters may offer transformative avenues for addressing the increasing burden of Alzheimer's disease and Parkinson's disease.eng
dc.identifier.doi10.1080/13510002.2025.2592413
dc.identifier.other41396689
dc.identifier.urihttp://hdl.handle.net/10400.1/28028
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor & Francis Group
dc.relationIdentification of S-sulfhydration targets in Down Syndrome: the role of gasotransmitter hydrogen sulfide (H2S) signaling in neurodevelopment
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAlzheimer’s disease
dc.subjectGasotransmitters
dc.subjectParkinson’s disease
dc.subjectcarbon monoxide
dc.subjecthydrogen sulfide
dc.subjectneurogenesis
dc.subjectneuroprotection
dc.subjectnitric oxide
dc.titleUnraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIdentification of S-sulfhydration targets in Down Syndrome: the role of gasotransmitter hydrogen sulfide (H2S) signaling in neurodevelopment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FMED-NEU%2F1240%2F2021/PT
oaire.citation.issue1
oaire.citation.startPage2592413
oaire.citation.titleRedox Report
oaire.citation.volume31
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSimao
person.familyNameFilipa Santos
person.familyNameRodrigues
person.familyNameVitorino
person.givenNameSonia
person.givenNameDaniela
person.givenNameJoana
person.givenNameMarta
person.identifier.ciencia-id7917-DC57-F21B
person.identifier.ciencia-idFD19-6BD5-B69D
person.identifier.ciencia-id4615-FF5B-E951
person.identifier.orcid0000-0002-0245-0633
person.identifier.orcid0000-0001-6855-1763
person.identifier.orcid0000-0001-8918-7753
person.identifier.orcid0000-0001-8563-8975
person.identifier.ridU-9947-2018
person.identifier.scopus-author-id24067982400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicatione4df724e-8bad-4f99-8e8b-f888b3c93692
relation.isAuthorOfPublication072626b1-487f-4357-ad79-96731a1efa44
relation.isAuthorOfPublication77d5ce31-8446-468a-ace4-07cc05f8ed66
relation.isAuthorOfPublication94a8c9c7-6d95-40ac-805a-766e82851c62
relation.isAuthorOfPublication.latestForDiscoverye4df724e-8bad-4f99-8e8b-f888b3c93692
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