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- CytroCell: a computational study in aqueous solution and infrared spectroscopic structural characterizationPublication . Tixier, Anne-Sylvie Fabiano; Michel, Nicolas; Ciriminna, Rosaria; Petri, Giovanna Li; Angellotti, Giuseppe; Pagliaro, Mario; Garcia, AnaA COSMO-RS conductor-like screening model for realistic solvation and molecular dynamics simulations conducted in GROMACS were used to gain insight into the structure and behaviour of CytroCell citrus nanocellulose in aqueous and more complex solutions, including the green solvent dihydrolevoglucosenone. DRIFT spectroscopy was used to investigate the structure of CytroCell nanocellulose solid samples obtained via acoustic cavitation of lemon, orange, and red orange industrial processing waste. The computational and experimental results obtained are relevant to all forthcoming applications of this new family of nanocelluloses sustainably sourced from the citrus industry’s main waste product via the CytroCav circular economy process.
- Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.Publication . Simao, Sonia; Filipa Santos, Daniela; Teixeira, Mariana; Agostinho, Rafaela R.; Rodrigues, Joana; Vitorino, Marta; Araújo, Inês M.Alzheimer's disease and Parkinson's disease are the two most prevalent neurodegenerative disorders worldwide, both characterized by progressive neuronal loss. Despite distinct pathophysiological features, they share cellular dysfunctions such as abnormal protein aggregation, oxidative stress, and neuroinflammation, research into which might be beneficial for developing novel therapeutic strategies that could tackle both conditions. This review highlights the emerging role of the gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide as modulators of adult neurogenesis and neuroprotection in Alzheimer's disease and Parkinson's disease. We have gathered recent evidence demonstrating that these endogenous gases exert anti-inflammatory, antioxidant, and anti-apoptotic effects, and, critically, promote neurogenesis - suggesting a dual neuroprotective and neuroregenerative therapeutic potential. The unique physicochemical features of these gasotransmitters, including their ability to cross the blood-brain barrier and diffuse rapidly throughout the neural tissue, further support their suitability as candidates for innovative neuroregenerative treatments. While clinical translation remains challenging, harnessing the neurogenic and neuroprotective actions of these gasotransmitters may offer transformative avenues for addressing the increasing burden of Alzheimer's disease and Parkinson's disease.
- Tailored bacterial co-cultures improve Tisochrysis lutea growth and nutrient profiles under xenic conditions: a new pathway to improve microalgal productionPublication . Santos, Tamara; da Fonseca Simões, Beatriz; Rossetto, Veronica; Pereira, Hugo; Maia, Inês Beatriz; Oliveira, Marta; Esteves Lopes Navalho, João Carlos; Engelen, Aschwin; Varela, JoãoThe marine haptophyte Tisochrysis lutea is a valuable source of high-value compounds, including polyunsaturated fatty acids like docosahexaenoic acid, and pigments (e.g., fucoxanthin). However, high production costs and variability remain major challenges for its large-scale application in aquaculture, pharmaceuticals, and biotechnology industries. Therefore, strategies to enhance biomass production and quality are actively explored. In natural environments, T. lutea establishes mutualistic interactions with bacteria to obtain essential nutrients such as vitamin B12, yet the role of bacteria in industrial cultures remains poorly understood. In this study, 145 bacterial strains were isolated and taxonomically identified from industrial T. lutea cultures, with members of the class Gammaproteobacteria and Actinomycetia being the most prevalent. Forty isolates were screened individually in co-culture with T. lutea revealing strain-specific effects on growth and biochemical composition. Seven beneficial strains were used to design 21 tailored bacterial blends. Several consortia enhanced biomass production (up to 74 %) and increased key bioactive compounds, particularly methylcobalamin (up to 300 %). These findings demonstrate the potential of tailored bacterial consortia to enhance T. lutea productivity and nutritional quality under production-relevant xenic conditions, enabling strategic microbiome modulation for specific industrial goals.
- Aulas de toxicologia alimentarPublication . Braz, Nídia Maria Dias Azinheira RebeloA Toxicologia estuda os efeitos adversos das substâncias nos seres vivos ou em sistemas alternativos in vitro, como culturas de células ou de tecidos. Toxicologia alimentar é o ramo da Toxicologia que se ocupa dos agentes tóxicos veiculados pelos alimentos, quer sejam parte da sua constituição ou resultem de contaminação.
- Resilience of innovationPublication . Viana, Luiz; Pinto, HugoThe resilience of innovation approach extends the notion of resilience—commonly used to refer to socio-economic systems—to the innovation process. This text reviews conceptual perspectives on resilience (engineering, ecological, adaptive and transformative) and highlights innovation as a dynamic process, not just an outcome. Innovation resilience differs from related concepts such as innovation persistence and technological resilience, which focus on stability rather than the transformative nature of the process. In addition, we highlight that innovation resilience is a multi-level phenomenon and allows for the exploration of opportunities for social and environmental change in times of uncertainty.
- Resilient wireless sensor actor networks through multi-objective self-adaptationPublication . Gomes, Ruben; Correia, NoéliaWireless Sensor Actor Networks (WSAN) are a key enabler of Internet of Things applications that demand timely and reliable data exchange under dynamic conditions. Among the various domains that benefit from these networks, precision agriculture stands out, demanding adaptive strategies for effective monitoring and control. This study proposes a reinforcement learning approach that leverages the Operationalization construct of the Self-Orchestrated Web of Things (SOrWoT) framework to enhance the adaptability of Things’ internal operations. A problem is formulated as a Markov Decision Process, and a Deep Q-Learning agent is trained in a custom simulation environment to identify the most suitable Operationalizations for optimizing data accuracy and latency, under changing conditions and communication failures. The results show that during normal operation the agent favored parallel sensor data averaging to minimize read error, but after an actor failure and the consequent increase in sensor-to-actor distances, it adapted by prioritizing latency through faster Operationalization choices. Sensitivity analyses further confirmed the agent’s ability to adjust policies in response to partial failures, and to shifts in the relative importance of latency versus accuracy. These findings demonstrate that reinforcement learning can autonomously optimize WSAN performance, contributing to resilient and self-adaptive systems.
- The southern african stone age site index (SASSI): a spatial, chronological and contextual resource for archaeological researchPublication . Hallinan, EmilySouthern Africa possesses a deep archaeological record, spanning more than a million years, which has attracted over a century of research. As a result, it offers one of the densest and most detailed pictures of Stone Age occupation history in Africa. However, certain time periods and regions have featured more prominently in research, particularly the later Middle Stone Age of the coastal and mountain zones. Moreover, the modern emphasis on absolute dating and well-resolved chronologies often excludes open-air and surface sites from reviews and syntheses, meaning that environments lacking deep, stratified rock shelters remain underrepresented. To address this, the Southern African Stone Age Site Index (SASSI) provides a centralised, openly accessible resource for archaeological research, featuring 492 reported Earlier, Middle and Later Stone Age sites from South Africa, Lesotho, Eswatini and Namibia. It includes both dated and undated sites, and encompasses diverse contexts. The database integrates spatial, chronological, cultural and contextual information, following FAIR data principles. While previous synthetic datasets have emphasised chronology and systematics, SASSI instead prioritises spatial coverage, offering a foundation for new perspectives on demography, settlement patterns, and landscape use in southern Africa’s past.
- Cineclube de Faro (Faro Film Club): Film screenings database (1956-1974)Publication . Duarte, Joana Isabel; Carrega, JorgeScreening dates, film titles, and exhibition venues were collected through a full review of programmes from the Faro Film Club. These materials were consulted at the Arquivo Histórico do Porto and the Library of the Cinemateca Portuguesa. Both PDF files (for consultation) and CSV files (for data reuse) are included. The data analysis will be published in a forthcoming artcile. All documents included here are under a two-year embargo until those results are released.
- IFM - X International forum on management artificial intelligence in the new organizational era 7 - 9 May 2026: book of abstractsPublication .The IFM - International Forum on Management is an annual technical and scientific event, organized jointly by five Portuguese higher education institutions (HEIs): the School of Hospitality and Tourism of Estoril, the Polytechnic Institute of Setúbal, the Open University, the University of Algarve and the University of Évora. Now in its 10th year, the event has firmly established itself as an international reference point, bringing together researchers and professionals who have advanced research and practice in various fields of management and related areas. The forum provides a valuable platform for reflection and knowledge sharing, promoting the dissemination of scientific knowledge and the development of effective organizational practices. The 10th edition will take place in Faro from 7 to 9 May 2026 and will be organized by the School of Management, Hospitality and Tourism at the University of Algarve.
- O Papel da Árvores nas Cidades – Sequestro de Carbono e Outros Serviços EcossistémicosPublication . Silva, Manuela Fernanda Gomes Moreira da; Matias, Pedro; João Teigão; Duarte, AmilcarAtingir a neutralidade carbónica exige a redução das emissões atuais de carbono e o aumento do seu sequestro. As cidades são responsáveis por 75 % das emissões globais e são particularmente vulneráveis às alterações climáticas, por concentrarem 55 % da população mundial, bem como edifícios e infraestruturas. A integração de árvores nas cidades apresenta diversos benefícios para a resiliência climática. Neste estudo, avaliaram-se o sequestro e armazenamento de carbono, a produção de O₂, a remoção de poluentes atmosféricos, a transpiração e o escoamento superficial evitado, assegurados por nove espécies arbóreas presentes em duas cidades do Algarve (Portugal). Verificou-se que C. equisetifolia, E. globulus, J. mimosifolia, P. nigra e Q. suber sequestraram mais CO₂ e produziram mais O₂; Q. suber e E. globulus armazenaram mais carbono; e J. mimosifolia, P. × hispanica, P. nigra e Q. suber removeram mais poluentes atmosféricos, apresentaram maior transpiração e evitaram maior volume de escoamento superficial. A seleção adequada das árvores permite a complementaridade dos diversos benefícios para as comunidades urbanas.