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Development of a multiresidue method for the determination of 24 pharmaceuticals in clams by QuEChERS and liquid chromatography-triple quadrupole tandem mass spectrometry

2019-04Artigo científico Acesso restrito
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dc.contributor.authorRodrigues, Joao
dc.contributor.authorAlbino, Stephanie
dc.contributor.authorSilva, Sofia
dc.contributor.authorCravo, Alexandra
dc.contributor.authorCardoso, Vitor Vale
dc.contributor.authorBenoliel, Maria Joao
dc.contributor.authorAlmeida, Cristina M. M.
dc.date.accessioned2020-07-24T10:52:34Z
dc.date.available2020-07-24T10:52:34Z
dc.date.issued2019-04
dc.description.abstractData on different therapeutic classes of pharmaceutical compounds (PhCs) in clams or other bivalves living in natural conditions are scarce. The aim of this work was the optimization and validation of a method for the determination of PhCs in clams for further evaluation of any potential human exposure risk due to their consumption. A quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach is proposed for sample clean-up and concentration of 24 PhCs in clams, with subsequent analysis by liquid chromatography-tandem mass spectrometry. This method showed a good linear range for all PhCs with determination coefficients (r(2)) between 0.9949 and 0.9993 and coefficients of variation (CVm) lower than 5.5%. This method allowed the quantification of target compounds at trace concentration levels (ngg(-1)), being the most abundant PhC in clam caffeine. This PhC was detected in more than 70% of samples with concentrations ranging from 0.10 to 12ngg(-1) wet weight.
dc.description.sponsorshipEuropean Commission, LIFE Environment Programme, "LIFE Impetus - Improving current barriers for controlling pharmaceutical compounds in urban wastewater treatment plants" [LIFE14 ENV/PT/000739]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s12161-018-01418-y
dc.identifier.issn1936-9751
dc.identifier.issn1936-976X
dc.identifier.urihttp://hdl.handle.net/10400.1/14377
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.subjectPersonal care products
dc.subjectEndocrine disrupting compounds
dc.subjectHepatitis-A-virus
dc.subjectRuditapes-philippinarum
dc.subjectImmune parameters
dc.subjectVeterinary drugs
dc.subjectFish
dc.subjectMollusks
dc.subjectDiclofenac
dc.subjectIbuprofen
dc.titleDevelopment of a multiresidue method for the determination of 24 pharmaceuticals in clams by QuEChERS and liquid chromatography-triple quadrupole tandem mass spectrometry
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage851
oaire.citation.issue4
oaire.citation.startPage838
oaire.citation.titleFood Analytical Methods
oaire.citation.volume12
person.familyNameCravo
person.givenNameAlexandra
person.identifier.ciencia-id7419-EE20-8039
person.identifier.orcid0000-0002-2569-3929
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationf19c20c8-9654-43db-841b-2c6f14979df5
relation.isAuthorOfPublication.latestForDiscoveryf19c20c8-9654-43db-841b-2c6f14979df5

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