Repository logo
 
Publication

Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs

2018Journal article Restricted access
Simple item page
dc.contributor.authorCunha, Ludmylla
dc.contributor.authorRosa Da Costa, Ana
dc.contributor.authorLourenço, João P.
dc.contributor.authorButtini, Francesca
dc.contributor.authorGrenha, Ana
dc.date.accessioned2019-01-15T16:09:03Z
dc.date.available2019-01-15T16:09:03Z
dc.date.issued2018
dc.description.abstractPulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity. This work aimed at using fucoidan as matrix of inhalable microparticles that associate two first-line antitubercular drugs, for an application in pulmonary tuberculosis therapy. Fucoidan is composed of fucose and sulphated sugar residues, moieties described as being recognised by surface receptors of alveolar macrophages, which host mycobacteria. Inhalable fucoidan microparticles loaded with antitubercular drugs were successfully produced with high association efficiencies of either isoniazid (95%) or rifabutin (81%). The microparticles evidenced no cytotoxicity on lung epithelial cells (A549). However, rifabutin-loaded microparticles showed a certain degree of toxicity on macrophage-like cells (THP-1) at the highest tested concentration (1 mg/mL). Furthermore, microparticles showed favourable aerodynamic properties for deep lung delivery (MMAD 2.0-3.8 µm) and, thus, show potential for an application as inhalable tuberculosis therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLudmylla Cunha, Ana M. Rosa da Costa, João P. Lourenço, Francesca Buttini & Ana Grenha (2018) Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs, Journal of Microencapsulation, 35:4, 392-405, DOI: 10.1080/02652048.2018.1513089pt_PT
dc.identifier.doi10.1080/02652048.2018.1513089pt_PT
dc.identifier.issn0265-2048
dc.identifier.urihttp://hdl.handle.net/10400.1/12292
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationFighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
dc.relationCentre of Marine Sciences
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/02652048.2018.1513089pt_PT
dc.subjectA549 cellspt_PT
dc.subjectAdministrationpt_PT
dc.subjectAntitubercular agentspt_PT
dc.subjectCell linept_PT
dc.subjectDrug carrierspt_PT
dc.subjectDrug liberationpt_PT
dc.subjectHumanspt_PT
dc.subjectIsoniazidpt_PT
dc.subjectPolysaccharidespt_PT
dc.subjectRifabutinpt_PT
dc.subjectInhalationpt_PT
dc.titleSpray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0094%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.citation.endPage405pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage392pt_PT
oaire.citation.titleJournal of Microencapsulationpt_PT
oaire.citation.volume35pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCunha
person.familyNameRosa da Costa
person.familyNameLourenço
person.familyNameGrenha
person.givenNameLudmylla Costa
person.givenNameAna M
person.givenNameJoão P.
person.givenNameAna
person.identifier305029
person.identifier634248
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.ciencia-idF81F-A1F0-2A7C
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0003-2620-5760
person.identifier.orcid0000-0003-0225-9537
person.identifier.orcid0000-0002-0501-6672
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridE-2165-2012
person.identifier.ridA-7758-2008
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id53986075100
person.identifier.scopus-author-id57195730600
person.identifier.scopus-author-id8607930100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication90a94579-d2cb-47a7-8f9f-991b29dfa9d1
relation.isAuthorOfPublication0ca8c16f-6881-4662-bafc-cc51c5ce8d88
relation.isAuthorOfPublicationf66ab886-d989-4c1d-9550-527507723c26
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublication.latestForDiscovery1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isProjectOfPublication0d670626-9c73-4df8-b1ce-45987ba99ed5
relation.isProjectOfPublication42f9a7c8-8d5c-41d5-b490-9bb0334ea269
relation.isProjectOfPublicatione13142f2-37b8-4b5a-b2cd-352e62003184
relation.isProjectOfPublication9afed05e-58cb-478e-acc7-625439f9c745
relation.isProjectOfPublication.latestForDiscovery0d670626-9c73-4df8-b1ce-45987ba99ed5

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Journal of Microencapsulation 2018.pdf
Size:
985.57 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCT2-Artigos (em revistas ou actas indexadas)