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Toxin profile of Ostreopsis cf. ovata from Portuguese continental coast and Selvagens Islands (Madeira, Portugal)

2020-07Journal article Restricted access
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dc.contributor.authorSoliño, Lucia
dc.contributor.authorGarcia-Altares, Maria
dc.contributor.authorGodinho, Lia
dc.contributor.authorReis Costa, Pedro
dc.date.accessioned2021-06-24T11:35:25Z
dc.date.available2021-06-24T11:35:25Z
dc.date.issued2020-07
dc.description.abstractThe toxigenic dinoflagellate Ostreopsis cf. ovata is known to produce a range of palytoxin (PLTX) - related compounds named ovatoxins (OVTX). O. cf. ovata presents a wide variability in toxin production and its toxic profile is strain-specific. Several OVTXs, denominated from -a to -h and -I have been reported from different strains of this benthic microalgae up to now, mainly in Mediterranean isolates. However, less is known about the toxin profile of the strains present in the Atlantic coasts of Europe. In this work, strains of O. cf. ovata isolated from the South coast of Portugal mainland (Algarve) and Selvagens Island (Madeira, Portugal) were cultured and tested for toxicity by hemolytic assay. Toxin profiles were qualitatively elucidated by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS). The strain from Algarve presented lower toxic potency than the strain from Selvagens island (12.3 against 54.8 pg of PLTX equivalents per cell) showing in both cases the characteristic toxin profile of Mediterranean strains. The major component, OVTX-a, was concomitant with OVTX from -b to -g and isobaric PLTX. Regarding the morphological characteristics of these strains, as well as their toxin fingerprint, it is likely they are closely related to strains from Mediterranean coasts. The present study reports for the first time the occurrence of several OVTX congeners and iso-PLTX in O. cf. ovata from Portuguese waters. This study provides valuable information to characterize the risk of OVTXs-related outbreaks in Portugal.
dc.description.sponsorshipSNMB-INOV: Innovation for a more competitive shellfish sector
dc.description.sponsorshipFEDEREuropean Commission
dc.description.sponsorshipEUEuropean Commission [700036]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.toxicon.2020.04.102
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10400.1/16435
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectOvatoxin
dc.subjectIsobaric-palytoxin
dc.subjectHarmful algal blooms
dc.subjectBenthic dinoflagellates
dc.subjectLiquid chromatography-high resolution mass spectrometry
dc.subject.otherPharmacology & pharmacy
dc.titleToxin profile of Ostreopsis cf. ovata from Portuguese continental coast and Selvagens Islands (Madeira, Portugal)
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/151746/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157544/PT
oaire.citation.endPage101
oaire.citation.startPage91
oaire.citation.titleToxicon
oaire.citation.volume181
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSoliño
person.familyNameReis Costa
person.givenNameLucia
person.givenNamePedro
person.identifier600820
person.identifier.ciencia-id2F12-68AC-8F6C
person.identifier.ciencia-idC911-9715-E547
person.identifier.orcid0000-0001-8356-5688
person.identifier.orcid0000-0001-6083-470X
person.identifier.ridN-1908-2019
person.identifier.scopus-author-id7201895802
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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