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Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

2017Journal article Open Access
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dc.contributor.authorNunes, Ricardo
dc.contributor.authorPasko, Pawel
dc.contributor.authorTyszka-Czochara, Malgorzata
dc.contributor.authorSzewczyk, Agnieszka
dc.contributor.authorSzlosarczyk, Marek
dc.contributor.authorSaraiva de Carvalho, Isabel
dc.date.accessioned2018-12-07T14:58:24Z
dc.date.available2018-12-07T14:58:24Z
dc.date.issued2017
dc.description.abstractContext: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90mg AAE/g dw and 783.48mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 mu g/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.
dc.description.sponsorshipFCT, Fundacao para a Ciencia e a Tecnologia of Portugal [SFRH/BSA/139/2014]
dc.identifier.doi10.1080/13880209.2016.1230636
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.urihttp://hdl.handle.net/10400.1/12005
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor & Francis Ltd
dc.relationMICROMEDRONHO - DESIGNER DE MICROCÁPSULAS DE ARBUTUS UNEDO FOLHAS, FRUTOS E FLORES POR SPRAY DRYING PARA SUPLEMENTOS E ALIMENTOS FUNCIONAIS
dc.subjectLead-induced cytotoxicity
dc.subjectCrataegus-monogyna
dc.subjectEssential oil
dc.subjectGallic acid
dc.subjectIn-vitro
dc.subjectAntimicrobial activities
dc.subjectPathogenic bacteria
dc.subjectProtocatechuic acid
dc.subjectLavandula-luisieri
dc.subjectPhenolic-compounds
dc.titleAntibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMICROMEDRONHO - DESIGNER DE MICROCÁPSULAS DE ARBUTUS UNEDO FOLHAS, FRUTOS E FLORES POR SPRAY DRYING PARA SUPLEMENTOS E ALIMENTOS FUNCIONAIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F51888%2F2012/PT
oaire.citation.endPage123
oaire.citation.issue1
oaire.citation.startPage114
oaire.citation.titlePharmaceutical Biology
oaire.citation.volume55
person.familyNameNunes
person.familyNameSaraiva de Carvalho
person.givenNameRicardo
person.givenNameIsabel Maria Marques
person.identifier.ciencia-id591A-3777-B036
person.identifier.orcid0000-0002-0500-6300
person.identifier.orcid0000-0001-8057-3404
person.identifier.scopus-author-id35995183800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublicationaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isAuthorOfPublication.latestForDiscoverya28aa189-2764-4b32-9698-b0f242e415ab
relation.isProjectOfPublicationd46c1c6d-25cc-477e-a3d3-9b10e2d9e61a
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