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Response of antioxidant systems to copper in the gills of the clam Ruditapes decussatus

2002Journal article Restricted access
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dc.contributor.authorGeret, Florence
dc.contributor.authorSerafim, Angela
dc.contributor.authorBarreira, Luísa
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-05-28T09:41:48Z
dc.date.available2020-05-28T09:41:48Z
dc.date.issued2002
dc.description.abstractCopper (Cu) is an essential element for biological systems, however, when present in excess, is toxic. Metallothioneins can play an important role in Cu homeostasis and detoxification. Moreover, Cu can catalyse the production of toxic hydroxyl radicals that cause lipid peroxidation but defence systems in the cells can limit the oxidative damage. The present study was performed to investigate the effect of three Cu concentrations (0.5, 2.5 and 25 mug l(-1)) on the response of antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), selenium-dependent glutathion peroxidase and total glutathion peroxidase), total proteins, metallothioneins (MT), malondialdehyde (MDA) concentrations in the gills of the clam, Ruditapes decussatus. The activity of antioxidant enzymes and total proteins, MT and MDA concentrations were measured in the gills of the clams after 1, 3, 7, 14, 21 and 28 days of Cu exposure. Results indicate that Cu only induces an imbalance in the oxygen metabolism during the first week of Cu exposure due to a decrease in mitochondrial SOD and CAT, selenium-dependent and total glutathion peroxidase activities. Cu also causes lipid peroxidation, measured by the MDA formation, that was Cu dependent. In the gills of clams exposed to 25 mug Cu/l, the excess of Cu triggers the induction of MT synthesis after 3 days. of exposure.pt_PT
dc.description.sponsorshipsupported by a grant funded by FCT (Fundação para a Ciência e a Tecnologia) of the Ministry of Science and Technology of Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/S0141-1136(02)00164-2pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10400.1/13963
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidant enzymespt_PT
dc.subjectSuperoxide dismutasept_PT
dc.subjectCatalasept_PT
dc.subjectGlutathion peroxidasept_PT
dc.subjectMetallothioneinpt_PT
dc.subjectLipid peroxidationpt_PT
dc.subjectClampt_PT
dc.subjectCooperpt_PT
dc.titleResponse of antioxidant systems to copper in the gills of the clam Ruditapes decussatuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage417pt_PT
oaire.citation.issue3-5pt_PT
oaire.citation.startPage413pt_PT
oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume54pt_PT
person.familyNameGeret
person.familyNamePereira Serafim
person.familyNameBarreira
person.familyNameBebianno
person.givenNameFlorence
person.givenNameMaria Angela
person.givenNameLuísa
person.givenNameMaria
person.identifier.ciencia-id9C18-090A-5E3D
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-0716-7172
person.identifier.orcid0000-0002-1165-0645
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication90b06d61-f303-4155-b503-3368166b7782
relation.isAuthorOfPublication0e42fc03-7052-438d-952b-b3caa5bdc36a
relation.isAuthorOfPublicationce3d77be-25df-4257-b5b3-aca8cff24116
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32

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