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A hybrid modelling approach for eliciting health state preferences: the Portuguese EQ-5D-5L value set

2019-12Journal article Restricted access
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dc.contributor.authorFerreira, Pedro L.
dc.contributor.authorAntunes, Patricia
dc.contributor.authorFerreira, Lara
dc.contributor.authorPereira, LN
dc.contributor.authorRamos-Goni, Juan M.
dc.date.accessioned2020-07-24T10:50:47Z
dc.date.available2020-07-24T10:50:47Z
dc.date.issued2019-12
dc.description.abstractBackground The EQ-5D is a generic preference-based quality of life measure considered useful for supporting clinical and policy decisions by providing utility values that can easily be converted into quality-adjusted life years to be integrated in cost-utility economic evaluations. Although the three-level classification system of the EuroQol questionnaire (EQ-5D-3L) is still the most popular preference-based instrument used worldwide, several studies reported a ceiling effect on this version, especially in healthy and/or young individuals. In 2009, the EuroQol Group introduced a five-level EQ-5D, which expands the descriptive system from three to five levels within the same five dimensions. For this version to be used in health economic evaluation, societal values need to be assigned to the 3125 health states generated by this instrument. Objectives The aims of this study were to elicit the EQ-5D-5L health state preferences from the general Portuguese population and to derive the Portuguese value set for the EQ-5D-5L. Methods A representative sample of the Portuguese general population aged above 18 years was stratified by age and gender (n = 1451). Between October 2015 and July 2016, 28 interviewers carried out a series of 1-h-long computer-assisted personal interviews following the EuroQol Valuation Technology protocol. Each interview included the valuation of ten health states using the composite time trade-off (cTTO) and seven pairs of discrete choice experiments (DCEs). A standardized tool for quality control was used to assess the quality of the data as well as direct supervision and cross-examination of 10% of the global sample size. Data from both cTTO and DCE valuation tasks were modelled using a censored heteroskedastic hybrid model. Results Interviewers complied with the quality control protocol in providing high-quality valuation data. The hybrid econometric model had consistent and significant parameters. The derived societal values for the Portuguese population ranged from - 0.603 to 1. Conclusion This study provided the Portuguese value set for the EQ-5D-5L on the basis of a hybrid econometric model using cTTO and DCE data. These results represent the preferences of the Portuguese population and are recommended to inform health decision-making in Portugal.
dc.description.sponsorshipEuroQol Research Foundation
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s11136-019-02226-5
dc.identifier.eissn1573-2649
dc.identifier.issn0962-9343
dc.identifier.urihttp://hdl.handle.net/10400.1/14153
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.subjectTime trade-off
dc.subjectDescriptive systems
dc.subjectSf-6D
dc.subjectValuation
dc.subjectChoice
dc.subjectUs
dc.subjectEuroqol
dc.subjectEQ-5D-5L
dc.subjectPreferences
dc.subjectPortuguese value set
dc.subjectComposite time trade-of
dc.subjectDiscrete choice experiment
dc.subjectQuality of life
dc.titleA hybrid modelling approach for eliciting health state preferences: the Portuguese EQ-5D-5L value set
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3175
oaire.citation.issue12
oaire.citation.startPage3163
oaire.citation.titleQuality of Life Research
oaire.citation.volume28
person.familyNameFerreira
person.familyNameNobre Pereira
person.givenNameLara
person.givenNameLuis
person.identifier.ciencia-id761A-3037-8E22
person.identifier.ciencia-id6114-E329-972E
person.identifier.orcid0000-0003-2378-7750
person.identifier.orcid0000-0003-0917-7163
person.identifier.ridB-7575-2019
person.identifier.scopus-author-id24491766400
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicatione93501ac-9707-4e92-bb2c-cc91bc09b428
relation.isAuthorOfPublication090a6604-b604-414b-a8d2-c4dc731b7b51
relation.isAuthorOfPublication.latestForDiscovery090a6604-b604-414b-a8d2-c4dc731b7b51

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