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The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression data

2021-08Journal article Open access
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dc.contributor.authorMalato, João
dc.contributor.authorSotzny, Franziska
dc.contributor.authorBauer, Sandra
dc.contributor.authorFreitag, Helma
dc.contributor.authorFonseca, André
dc.contributor.authorGrabowska, Anna D.
dc.contributor.authorGraça, Luís
dc.contributor.authorCordeiro, Clara
dc.contributor.authorNacul, Luís
dc.contributor.authorLacerda, Eliana M.
dc.contributor.authorCastro-Marrero, Jesus
dc.contributor.authorScheibenbogen, Carmen
dc.contributor.authorWestermeier, Francisco
dc.contributor.authorSepúlveda, Nuno
dc.date.accessioned2021-09-15T14:05:32Z
dc.date.available2021-09-15T14:05:32Z
dc.date.issued2021-08
dc.description.abstractPeople with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often report a high frequency of viral infections and flu-like symptoms during their disease course. Given that this reporting agrees with different immunological abnormalities and altered gene expression profiles observed in the disease, we aimed at answering whether the expression of the human angiotensin-converting enzyme 2 (ACE2), the major cell entry receptor for SARS-CoV-2, is also altered in these patients. In particular, a low expression of ACE2 could be indicative of a high risk of developing COVID-19. We then performed a meta-analysis of public data on CpG DNA methylation and gene expression of this enzyme and its homologous ACE protein in peripheral blood mononuclear cells and related subsets. We found that patients with ME/CFS have decreased methylation levels of four CpG probes in the ACE locus (cg09920557, cg19802564, cg21094739, and cg10468385) and of another probe in the promoter region of the ACE2 gene (cg08559914). We also found a decreased expression of ACE2 but not of ACE in patients when compared to healthy controls. Accordingly, in newly collected data, there was evidence for a significant higher proportion of samples with an ACE2 expression below the limit of detection in patients than healthy controls. Altogether, patients with ME/CFS can be at a higher COVID-19 risk and, if so, they should be considered a priority group for vaccination by public health authorities. To further support this conclusion, similar research is rec ommended for other human cell entry receptors and cell types, namely, those cells targeted by the virus.pt_PT
dc.description.sponsorshipR01AI103629; PF8947pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.heliyon.2021.e07665pt_PT
dc.identifier.eissn2405-8440
dc.identifier.urihttp://hdl.handle.net/10400.1/17119
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMyalgic encephalomyelitis/chronic fatiguept_PT
dc.subjectSyndromept_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectACE2pt_PT
dc.subjectGene expressionpt_PT
dc.subjectDNA methylationpt_PT
dc.titleThe SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression datapt_PT
dc.title.alternativeA enzima conversor de angiotensina sars-CoV-2 (ACE2) em encefalomielite miálgica/síndrome da fadiga crônica: Uma meta-análise dos dados de metilação do DNA público e dados de expressão genéticapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157257/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/75620/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/75391/PT
oaire.citation.issue8pt_PT
oaire.citation.startPagee07665pt_PT
oaire.citation.titleHeliyonpt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.fundingStreamOE
person.familyNameFonseca
person.familyNameHenrique Cordeiro
person.givenNameAndré Filipe Afonso de Sousa
person.givenNameClara Maria
person.identifier.ciencia-id0B1D-8695-6ADB
person.identifier.ciencia-idC71E-21A1-E882
person.identifier.orcid0000-0002-1026-6078
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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