EGFR and EML4-ALK updated therapies in non-small cell lung cancer.

Mello, Ramon Andrade de; Liu, Davi J J; Aguiar, Pedro N; Tadokoro, Hakaru

http://hdl.handle.net/10400.1/9705

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Authors

Mello, Ramon Andrade de

Liu, Davi J J

Aguiar, Pedro N

Tadokoro, Hakaru

Abstract(s)

BACKGROUND: Non-small cell lung cancer is the leading cancer-related cause of death.OBJECTIVE: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising patents.METHOD: A literature search of PubMed database was carried out to identify recent Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies on NSCLC. We conducted a search to find new therapy strategies, new biomarkers, and selected five patents we find relevant.RESULTS: Over the last few years, identification of cancer harboring epidermal growth factor receptor mutations (EGFR) or chromosomal rearrangements of anaplastic lymphoma kinase (ALK) led to new ways in classifying and treating NSCLC. On the other hand, acquired resistance are a constantly challenge in the management of patients with these mutations and new drugs options are in development to improve and amplify treatment strategies.CONCLUSIONS: Currently, EGFR TKIs (e.g.: erlotinib, gefitinib, osimertinib) and ALK inhibitors (crizotinib, ceritinib, alectinib) provided a new face for advanced NSCLC outcomes. To understand the disease molecular profile is mandatory to define the best approach for each patient.