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Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures

2015Journal article Open Access
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dc.contributor.authorCarreira, Bruno P.
dc.contributor.authorSantos, Daniela F.
dc.contributor.authorSantos, Ana Isabel
dc.contributor.authorCarvalho, Caetana M.
dc.contributor.authorAraújo, Inês
dc.date.accessioned2018-12-07T14:58:25Z
dc.date.available2018-12-07T14:58:25Z
dc.date.issued2015
dc.description.abstractHippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) in the hippocampus. However, little is known about the role of NO in the survival and differentiation of newborn cells in the injured dentate gyrus. Here we investigated the role of NO following seizures in the regulation of proliferation, migration, differentiation, and survival of NSC in the hippocampus using the kainic acid (KA) induced seizuremouse model. We show that NO increased the proliferation of NSC and the number of neuroblasts following seizures but was detrimental to the survival of newborn neurons. NO was also required for the maintenance of long-term neuroinflammation. Taken together, our data show that NO positively contributes to the initial stages of neurogenesis following seizures but compromises survival of newborn neurons.
dc.description.sponsorshipFoundation for Science and Technology (FCT, Portugal); COMPETE; FEDER [PTDC/SAU-NEU/102612/2008, PTDC/NEU-OSD/0473/2012, PEst-C/SAU/LA0001/2013-2014, PEst-OE/EQB/LA0023/2013-2014]; FCT, Portugal [SFRH/BPD/78901/2011, SFRH/BD/77903/2011]
dc.identifier.doi10.1155/2015/451512
dc.identifier.issn1942-0900
dc.identifier.issn1942-0994
dc.identifier.urihttp://hdl.handle.net/10400.1/12015
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHindawi Publishing Corporation
dc.relationEnhancement of endogenous neurogenesis by nitric oxide: identification of S-nitrosylation targets
dc.relationStrategic Project - LA 1 - 2011-2012
dc.relation2013 - Strategic Project
dc.relationPHYSIOLOGICAL ROLE OF CALPAINS: HOW DO CALPAINS REGULATE CELL PROLIFERATION AND MIGRATION IN THE BRAIN
dc.subjectTraumatic brain injury
dc.subjectGrowth factor receptor
dc.subjectNeural stem cells
dc.subjectDentate gyrus
dc.subjectAdult rat
dc.subjectSubventricular zone
dc.subjectNeuropeptide Y
dc.subjectAxonal projections
dc.subjectPrecursor cells
dc.subjectProliferation
dc.titleNitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnhancement of endogenous neurogenesis by nitric oxide: identification of S-nitrosylation targets
oaire.awardTitleStrategic Project - LA 1 - 2011-2012
oaire.awardTitle2013 - Strategic Project
oaire.awardTitlePHYSIOLOGICAL ROLE OF CALPAINS: HOW DO CALPAINS REGULATE CELL PROLIFERATION AND MIGRATION IN THE BRAIN
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-NEU%2F102612%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FNEU-OSD%2F0473%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FLA0001%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F78901%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F77903%2F2011/PT
oaire.citation.startPage451512
oaire.citation.titleOxidative Medicine and Cellular Longevity
oaire.fundingStream5876-PPCDTI
oaire.fundingStream3599-PPCDT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameFilipa Santos
person.familyNameSantos
person.familyNamePombinho de Araújo
person.givenNameDaniela
person.givenNameAna Isabel
person.givenNameInês Maria
person.identifierF-4703-2012
person.identifier.ciencia-id7917-DC57-F21B
person.identifier.ciencia-idA31D-E831-28E8
person.identifier.ciencia-idD11F-D4CA-2947
person.identifier.orcid0000-0001-6855-1763
person.identifier.orcid0000-0003-2070-0285
person.identifier.orcid0000-0002-2438-0111
person.identifier.scopus-author-id55019179900
person.identifier.scopus-author-id56271084100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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