Repository logo
 
Publication

Duplication of Dio3 genes in teleost fish and their divergent expression in skin during flatfish metamorphosis

2017-05Journal article Restricted access
Simple item page
dc.contributor.authorAlves, Ricardo
dc.contributor.authorCardoso, João CR
dc.contributor.authorHarboe, T.
dc.contributor.authorMartins, Rute
dc.contributor.authorManchado, M.
dc.contributor.authorNorberg, B.
dc.contributor.authorPower, Louise
dc.date.accessioned2019-11-20T15:07:36Z
dc.date.available2019-11-20T15:07:36Z
dc.date.issued2017-05
dc.description.abstractDeiodinase 3 (Dio3) plays an essential role during early development in vertebrates by controlling tissue thyroid hormone (TH) availability. The Atlantic halibut (Hippoglossus hippoglossus) possesses duplicate dio3 genes (dio3a and dio3b). Expression analysis indicates that dio3b levels change in abocular skin during metamorphosis and this suggests that this enzyme is associated with the divergent development of larval skin to the juvenile phenotype. In larvae exposed to MMI, a chemical that inhibits TH production, expression of dio3b in ocular skin is significantly up-regulated suggesting that THs normally modulate this genes expression during this developmental event. The molecular basis for divergent dio3a and dio3b expression and responsiveness to MMI treatment is explained by the multiple conserved TREs in the proximal promoter region of teleost dio3b and their absence from the promoter of dio3a. We propose that the divergent expression of dio3 in ocular and abocular skin during halibut metamorphosis contributes to the asymmetric pigment development in response to THs. (C) 2017 Elsevier Inc. All rights reserved.
dc.description.sponsorshipEuropean Community [FP7 222719]
dc.description.sponsorshipEuropen Regional Development Fund (ERDF)
dc.description.sponsorshipFoundation for Science and Technology (FCT), Portugal [Pest-C/MAR/LA0015/2013]
dc.description.sponsorshipFCT Portugal [Pest-C/MAR/LA0015/2013, SFRH/BD/69209/2010, SFRH/ BPD/66742/2009]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.ygcen.2017.01.002
dc.identifier.issn0016-6480
dc.identifier.issn1095-6840
dc.identifier.urihttp://hdl.handle.net/10400.1/13123
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAcademic Press Inc Elsevier Science
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHalibut hippoglossus-hippoglossus
dc.subjectThyroid-hormone transporters
dc.subjectIodothyronine deiodinases
dc.subjectAtlantic halibut
dc.subjectType-3 deiodinase
dc.subjectXenopus-laevis
dc.subjectGrowth-hormone
dc.subjectIii deiodinase
dc.subjectAmphibian metamorphosis
dc.subjectParalichthys-olivaceus
dc.titleDuplication of Dio3 genes in teleost fish and their divergent expression in skin during flatfish metamorphosis
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FMAR%2FLA0015%2F2013/PT
oaire.citation.endPage293
oaire.citation.startPage279
oaire.citation.titleGeneral and Comparative Endocrinology
oaire.citation.volume246
oaire.fundingStreamCOMPETE
person.familyNameCardoso
person.familyNameMartins
person.familyNamePower
person.givenNameJoão
person.givenNameRute Sofia Tavares
person.givenNameLouise
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-idA418-0899-1BD9
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0001-5804-2981
person.identifier.orcid0000-0001-5682-0006
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublication6bb5e817-b1b7-45fd-8e37-8b5fb225f662
relation.isAuthorOfPublicationde149379-bc44-4d59-b9ec-7aa0facc19ef
relation.isAuthorOfPublication.latestForDiscovery6bb5e817-b1b7-45fd-8e37-8b5fb225f662
relation.isProjectOfPublication54af5688-34c3-4241-8c3e-ae96076831ff
relation.isProjectOfPublication.latestForDiscovery54af5688-34c3-4241-8c3e-ae96076831ff

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Duplication of Dio3 genes - 13123.pdf
Size:
1.74 MB
Format:
Adobe Portable Document Format
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)