Multifocal infantile haemangioma: a diagnostic challenge

Torres, Erica; Rosa, João; Leaute-Labreze, Christine; Soares-de-Almeida, Luis

http://hdl.handle.net/10400.1/9424

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Authors

Torres, Erica

Rosa, João

Leaute-Labreze, Christine

Soares-de-Almeida, Luis

Abstract(s)

We describe a case of a newborn who presented with multiple dark red macules that developed into red-to-purple papules associated with thrombocytopaenia. Abdominal ultrasound showed multiple hyperechoic papules and nodules. Endothelial cells from a skin biopsy stained positively for endothelial cell glucose transporter 1, which was consistent with a diagnosis of multifocal infantile haemangioma. At the age of 2?months, the child developed intestinal bleeding and anaemia. Upper and lower endoscopies showed no intestinal haemangiomas. Oral treatment with propranolol (3?mg/kg/day) resulted in complete involution of the skin and hepatic haemangiomas over the period of treatment, which lasted until the child was aged 15?months. This is a rare case of multifocal cutaneous haemangioma with hepatic and probable intestinal involvement, successfully treated with propranolol.