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Cephalopods in neuroscience: regulations, research and the 3Rs

2014-03Journal article Restricted access
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dc.contributor.authorFiorito, Graziano
dc.contributor.authorAffuso, Andrea
dc.contributor.authorAnderson, David B
dc.contributor.authorBasil, Jennifer
dc.contributor.authorBonnaud, Laure
dc.contributor.authorBotta, Giovanni
dc.contributor.authorCole, Alison
dc.contributor.authorD'Angelo, Livia
dc.contributor.authorDe Girolamo, Paolo
dc.contributor.authorDennison, Ngaire
dc.contributor.authorDickel, Ludovic
dc.contributor.authorDi Cosmo, Anna
dc.contributor.authorDi Cristo, Carlo
dc.contributor.authorGestal, Camino
dc.contributor.authorFonseca, Rute
dc.contributor.authorGrasso, Frank
dc.contributor.authorKristiansen, Tore
dc.contributor.authorKuba, Michael
dc.contributor.authorMaffucci, Fulvio
dc.contributor.authorManciocco, Arianna
dc.contributor.authorMark, Felix Christopher
dc.contributor.authorMelillo, Daniela
dc.contributor.authorOsório, Daniel
dc.contributor.authorPalumbo, Anna
dc.contributor.authorPerkins, Kerry
dc.contributor.authorPonte, Giovanna
dc.contributor.authorRaspa, Marcello
dc.contributor.authorShashar, Nadav
dc.contributor.authorSmith, Jane
dc.contributor.authorSmith, David
dc.contributor.authorSykes, António V.
dc.contributor.authorVillanueva, Roger
dc.contributor.authorTublitz, Nathan
dc.contributor.authorZullo, Letizia
dc.contributor.authorAndrews, Paul
dc.date.accessioned2018-10-30T17:03:30Z
dc.date.available2018-10-30T17:03:30Z
dc.date.issued2014-03
dc.description.abstractCephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g. squid giant axon and synapse). On 1 January 2013, research using any of the about 700 extant species of "live cephalopods" became regulated within the European Union by Directive 2010/63/EU on the "Protection of Animals used for Scientific Purposes", giving cephalopods the same EU legal protection as previously afforded only to vertebrates. The Directive has a number of implications, particularly for neuroscience research. These include: (1) projects will need justification, authorisation from local competent authorities, and be subject to review including a harm-benefit assessment and adherence to the 3Rs principles (Replacement, Refinement and Reduction). (2) To support project evaluation and compliance with the new EU law, guidelines specific to cephalopods will need to be developed, covering capture, transport, handling, housing, care, maintenance, health monitoring, humane anaesthesia, analgesia and euthanasia. (3) Objective criteria need to be developed to identify signs of pain, suffering, distress and lasting harm particularly in the context of their induction by an experimental procedure. Despite diversity of views existing on some of these topics, this paper reviews the above topics and describes the approaches being taken by the cephalopod research community (represented by the authorship) to produce "guidelines" and the potential contribution of neuroscience research to cephalopod welfare.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s10158-013-0165-xpt_PT
dc.identifier.issn1354-2516
dc.identifier.urihttp://hdl.handle.net/10400.1/10900
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.subjectCephalopodspt_PT
dc.subjectDirective2010/63/EUpt_PT
dc.subjectAnimal welfarept_PT
dc.subject3Rspt_PT
dc.subjectNeurosciencespt_PT
dc.titleCephalopods in neuroscience: regulations, research and the 3Rspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage36pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage13pt_PT
oaire.citation.titleInvertebrate Neurosciencept_PT
oaire.citation.volume14pt_PT
person.familyNameSykes
person.givenNameAntónio
person.identifier107454
person.identifier.ciencia-id7510-6641-5A42
person.identifier.orcid0000-0002-5207-0612
person.identifier.ridC-3609-2012
person.identifier.scopus-author-id7102626426
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb9d55f95-5de8-40cf-82a3-96ec98c91a55
relation.isAuthorOfPublication.latestForDiscoveryb9d55f95-5de8-40cf-82a3-96ec98c91a55

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