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Unlocking the in vitroanti- inflammatory and antidiabetic potential of Polygonum maritimum

2017Journal article Open access
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dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorCustodio, Luisa
dc.contributor.authorLopes, Andreia
dc.contributor.authorOliveira, Marta
dc.contributor.authorNeng, Nuno R.
dc.contributor.authorNogueira, Jose M. F.
dc.contributor.authorMartins, Alice
dc.contributor.authorRauter, Amelia P.
dc.contributor.authorVarela, Joao
dc.contributor.authorBarreira, L.
dc.date.accessioned2018-12-07T14:58:24Z
dc.date.available2018-12-07T14:58:24Z
dc.date.issued2017
dc.description.abstractContext: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. Objective: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol and dichloromethane extracts of leaves and roots of the halophyte Polygonum maritimum L. Material and methods: Antioxidant activity was determined (up to 1mg/mL) as radical-scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), copper (CCA) and iron (ICA) chelating activities and iron reducing power (FRAP). NO production was measured in lipopolysaccharide (LPS)-stimulated macrophages for 24 h at concentrations up to 100 mu g/mL and antidiabetic potential was assessed by alpha-amylase and alpha-glucosidase inhibition (up to 10 g/mL) assays. The phytochemical composition of the extracts was determined by gas chromatography-mass spectrometry (GC-MS). Results: The methanol leaf extract had the highest activity against DPPH center dot (IC50 = 26 mu g/mL) and ABTS1(+)center dot (IC50 = 140 mu g FRAP (IC50 = 48 mu g/mL) and CCA (IC50 = 770 mu g/mL). Only the dichloromethane leaf extract (LDCM) showed anti-inflammatory activity (IC50 = 48 mu g/mL). The methanol root (IC50 = 19 mu g/mL) and leaf (IC50 = 29 mu g/mL) extracts strongly inhibited baker's yeast alpha-glucosidase, but LDCM had higher rat's alpha-glucosidase inhibition (IC50 = 2527 mu g/mL) than acarbose (IC50 = 4638 mu g/mL). GC-MS analysis identified beta-sitosterol, stigmasterol, 1-octacosanol and linolenic acid as possible molecules responsible for the observed bioactivities. Conclusions: Our findings suggest P. maritimum as a source of high-value health promoting commodities for alleviating symptoms associated with oxidative and inflammatory diseases, including diabetes.
dc.description.sponsorshipXtremeBio project - Foundation for Science and Technology (FCT) [PTDC/MAR-EST/4346/2012]; Portuguese National Budget; FCT [CCMAR/Multi/04326/ 2013, IF/00049/2012, SFRH/BPD/86071/2012, UID/Multi/00612/2013]
dc.identifier.doi10.1080/13880209.2017.1301493
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.urihttp://hdl.handle.net/10400.1/12000
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor & Francis Ltd
dc.subjectType 2 Diabetes mellitus
dc.subjectNitric oxide synthase
dc.subjectGlucosidase inhibitory activity
dc.subjectAlpha glucosidase
dc.subjectIn-Vitro
dc.subjectMedicinal plants
dc.subjectFatty acids
dc.subjectPhenolic composition
dc.subjectAqueous extract
dc.subjectEssential oil
dc.titleUnlocking the in vitroanti- inflammatory and antidiabetic potential of Polygonum maritimum
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1357
oaire.citation.issue1
oaire.citation.startPage1348
oaire.citation.titlePharmaceutical Biology
oaire.citation.volume55
person.familyNameRodrigues
person.familyNameCustódio
person.familyNameOliveira
person.familyNameVarela
person.familyNameBarreira
person.givenNameMaria João
person.givenNameLuísa
person.givenNameMarta
person.givenNameJoão
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.ciencia-idC618-E728-0B4C
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.orcid0000-0001-6793-8026
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0002-4077-855X
person.identifier.ridM-6101-2013
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
person.identifier.scopus-author-id55741416000
rcaap.rightsopenAccess
rcaap.typearticle
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