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Domain-dependent evolution explains functional homology of protostome and deuterostome complement C3-like proteins

2022-03Journal article Open access
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dc.contributor.authorPeng, Maoxiao
dc.contributor.authorLi, Zhi
dc.contributor.authorCardoso, João
dc.contributor.authorNiu, Donghong
dc.contributor.authorLiu, Xiaojun
dc.contributor.authorDong, Zhiguo
dc.contributor.authorLi, Jiale
dc.contributor.authorPower, Deborah
dc.date.accessioned2022-09-21T13:33:25Z
dc.date.available2022-09-21T13:33:25Z
dc.date.issued2022-03
dc.description.abstractComplement proteins emerged early in evolution but outside the vertebrate clade they are poorly characterized. An evolutionary model of C3 family members revealed that in contrast to vertebrates the evolutionary trajectory of C3-like genes in cnidarian, protostomes and invertebrate deuterostomes was highly divergent due to independent lineage and species-specific duplications. The deduced C3-like and vertebrate C3, C4 and C5 proteins had low sequence conservation, but extraordinarily high structural conservation and 2-chain and 3-chain protein isoforms repeatedly emerged. Functional characterization of three C3-like isoforms in a bivalve representative revealed that in common with vertebrates complement proteins they were cleaved into two subunits, b and a, and the latter regulated inflammation-related genes, chemotaxis and phagocytosis. Changes within the thioester bond cleavage sites and the a-subunit protein (ANATO domain) explained the functional differentiation of bivalve C3-like. The emergence of domain-related functions early during evolution explains the overlapping functions of bivalve C3-like and vertebrate C3, C4 and C5, despite low sequence conservation and indicates that evolutionary pressure acted to conserve protein domain organization rather than the primary sequence.pt_PT
dc.description.sponsorshipEMBRC.PT ALG-01-0145-FEDER-022121; 32072975
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fimmu.2022.840861pt_PT
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10400.1/18274
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectConserved domainpt_PT
dc.subjectFunctional homologuespt_PT
dc.subjectParallel evolutionpt_PT
dc.subjectComplement C3pt_PT
dc.subjectC4pt_PT
dc.subjectC5 familypt_PT
dc.subjectC3-like protein a-subunitpt_PT
dc.titleDomain-dependent evolution explains functional homology of protostome and deuterostome complement C3-like proteinspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.titleFrontiers in Immunologypt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePeng
person.familyNameLi
person.familyNameCardoso
person.familyNamePower
person.givenNameMaoxiao
person.givenNameZhi
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id0A1D-96B9-27EB
person.identifier.ciencia-id361E-ECE9-BC00
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-4855-1202
person.identifier.orcid0000-0002-4255-4170
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication9fe94b91-a00f-48b7-8a21-0228689e6164
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