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The effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis

2022-01Journal article Open access
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dc.contributor.authorMorvaridzadeh, Mojgan
dc.contributor.authorEstêvão, M. Dulce
dc.contributor.authorQorbani, Mostafa
dc.contributor.authorHeydari, Hafez
dc.contributor.authorHosseini, Ava sadat
dc.contributor.authorFazelian, Siavash
dc.contributor.authorBelančić, Andrej
dc.contributor.authorPersad, Emma
dc.contributor.authorRezamand, Gholamreza
dc.contributor.authorHeshmati, Javad
dc.date.accessioned2021-11-19T15:05:11Z
dc.date.available2021-11-19T15:05:11Z
dc.date.issued2022-01
dc.description.abstractBackground: Trivalent chromium is a trace element thought to have a beneficial effect on oxidative stress (OS) parameters and inflammation. This review aimed to investigate the dose-response of chromium and summarize the effects of chromium supplementation on OS parameters in the literature. Methods: MEDLINE, Scopus, Web of Science and Cochrane CENTRAL databases were searched for RCTs published from inception to January 2021 evaluating the effect of chromium supplementation on OS parameters, namely MDA, TBARS, SOD, TAS, CAT, GPx, and GSH. A random-effects model was used to pool data and calculated standard mean difference and 95 % confidence intervals. Quantified heterogeneity among studies was assessed through Cochrane’s I 2 values. Results: Nine studies enrolling 550 participants met the inclusion criteria. The obtained results indicate that chromium supplementation significantly increases TAC (SMD: 0.46; 95 % CI: 0.08, 0.84; I 2 = 00.0 % n = 2) and significantly decreases MDA levels (SMD: − 0.46; 95 % CI: − 0.86, -0.07; I 2 = 52.4 % n = 5). Supplementation did not significantly change CAT, GPx, GSH, SOD, TAS, and TBARS. Conclusion: Chromium supplementation may improve OS parameters, however, due to high heterogeneity observed in the included studies, these findings should be interpreted with caution. Large RCTs on various patient groups evaluating the impact of chromium supplementation are needed to allow an adequate generalization of the benefits of chromium on human health.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jtemb.2021.126879pt_PT
dc.identifier.eissn1878-3252
dc.identifier.urihttp://hdl.handle.net/10400.1/17333
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChromiumpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectMetabolic diseasept_PT
dc.subjectInflammatory diseasept_PT
dc.titleThe effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysispt_PT
dc.title.alternativeO efeito da ingestão de cromo nos parâmetros de estresse oxidativo: Revisão sistemática e meta-análisept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage126879pt_PT
oaire.citation.titleJournal of Trace Elements in Medicine and Biologypt_PT
oaire.citation.volume69pt_PT
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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