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Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae

2001-09Journal article Restricted access
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dc.contributor.authorGuerreiro, P. M.
dc.contributor.authorFuentes, T.
dc.contributor.authorPower, Deborah
dc.contributor.authorIngleton, P. M.
dc.contributor.authorFlik, G.
dc.contributor.authorCanario, Adelino V. M.
dc.date.accessioned2014-05-17T10:10:56Z
dc.date.available2014-05-17T10:10:56Z
dc.date.issued2001-09
dc.date.updated2014-05-13T10:29:51Z
dc.descriptionTexto integral disponível através do editor
dc.description.abstractThe effects of an N-terminal peptide (amino acids 1-38) of Fugu parathyroid hormone-related protein (PTHrP 1-38) on calcium regulation of larval sea bream were investigated in seawater (36 per thousand) and after transfer to dilute seawater (12 per thousand). Exposure to PTHrP 1-38 evoked a 1.5-fold increase in calcium influx in both full-strength and dilute seawater. Calcium influx in dilute seawater-adapted larvae was roughly one-half that observed in full-strength seawater controls. PTHrP 1-38 also reduced drinking of fish in seawater but, at all concentrations tested, was without effect in dilute seawater. The amount of water imbibed was 55% lower in dilute seawater than in seawater. PTHrP 1-38 exposure affected the calcium influx route: the main contribution of calcium uptake shifted from intestinal absorption to extraintestinal uptake, probably by the induction of a dose-dependent increase in branchial (active) transport. Moreover, seawater-adapted fish exposed to 1 nM and 10 mM PTHrP 1-38 experienced a 2.5-fold reduction in overall calcium efflux. Overall, the calciotropic action of PTHrP 1-38 resulted in a dose-dependent increase in net calcium balance.por
dc.identifier.citationGuerreiro, P. M.; Fuentes, T.; Power, D. M.; Ingleton, P. M.; Flik, G.; Canario, A. V. M.Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 281, 3, R855-R860, 2001.por
dc.identifier.issn0363-6119
dc.identifier.otherAUT: ACA00258; DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/3992
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Physiological Societypor
dc.relation.publisherversionhttp://ajpregu.physiology.org/content/281/3/R855por
dc.subjectHormonepor
dc.subjectN-terminalpor
dc.subjectCalcium regulationpor
dc.titleParathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvaepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage860por
oaire.citation.issue3por
oaire.citation.startPage855por
oaire.citation.titleAmerican Journal of Physiology - Regulatory, Integrative and Comparative Physiologypor
oaire.citation.volume281por
person.familyNameGuerreiro da Costa Guerreiro
person.familyNamePower
person.familyNameCanario
person.givenNamePedro Miguel
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifierA-2539-2009
person.identifier143624
person.identifier.ciencia-id5C13-965D-3148
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationd0a8a148-98e7-4899-8fb0-0b8afa91e4a4
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

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