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In vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish

2016-07Journal article Restricted access
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dc.contributor.authorBraga, Ana C.
dc.contributor.authorAlves, Ricardo N.
dc.contributor.authorMaulvault, Ana L.
dc.contributor.authorBarbosa, Vera
dc.contributor.authorMarques, António
dc.contributor.authorCosta, Pedro R.
dc.date.accessioned2017-04-07T15:57:02Z
dc.date.available2017-04-07T15:57:02Z
dc.date.issued2016-07
dc.description.abstractOkadaic acid (OA) and their derivatives are marine toxins responsible for the human diarrhetic shellfish poisoning (DSP). To date the amount of toxins ingested in food has been considered equal to the amount of toxins available for uptake by the human body. In this study, the OA fraction released from the food matrix into the digestive fluids (bioaccessibility) was assessed using a static in vitro digestion model. Naturally contaminated mussels (Mytilus galloprovincialis) and donax clams (Donax sp.), collected from the Portuguese coast, containing OA and dinophysistoxin-3 (DTX3) were used in this study. Bioaccessibility of OA total content was 88% and 75% in mussels and donax clams, respectively. Conversion of DTX3 into its parent compound was verified during the simulated digestive process and no degradation of these toxins was found during the process. This is the first study assessing the bioaccessibility of OA group toxins in naturally contaminated seafood. This study provides relevant new data that can improve and lead to more accurate food safety risk assessment studies concerning these toxins. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.fct.2016.01.008
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10400.1/9595
dc.language.isoeng
dc.peerreviewedyes
dc.relationPhysiological adaptations and strategies for toxins elimination by sellfish living with harmful blooms
dc.relationClimate change and bioaccumulation of emerging contaminants in marine organisms: Ecophysiology, toxicology and public health impacts
dc.relation.isbasedonWOS:000371556200007
dc.titleIn vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePhysiological adaptations and strategies for toxins elimination by sellfish living with harmful blooms
oaire.awardTitleClimate change and bioaccumulation of emerging contaminants in marine organisms: Ecophysiology, toxicology and public health impacts
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F113484%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103569%2F2014/PT
oaire.citation.endPage59
oaire.citation.startPage54
oaire.citation.titleFood and Chemical Toxicology
oaire.citation.volume89
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isProjectOfPublication35d155c3-9873-48c4-9f3c-c1eea1a37aeb
relation.isProjectOfPublicationb0fa60d2-110c-476c-9001-bb256e87fd9e
relation.isProjectOfPublication.latestForDiscovery35d155c3-9873-48c4-9f3c-c1eea1a37aeb

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