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Measuring healthy ageing: current and future tools

2023-07Journal article Open Access
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dc.contributor.authorSilva, Nádia
dc.contributor.authorRajado, Ana Teresa
dc.contributor.authorEsteves, Filipa
dc.contributor.authorBrito, David V.C.
dc.contributor.authorApolónio, Joana
dc.contributor.authorRoberto, Vânia
dc.contributor.authorBinnie, Alexandra
dc.contributor.authorAraújo, Inês Maria
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorBragança, José
dc.contributor.authorCastelo-Branco, Pedro
dc.date.accessioned2023-09-11T15:59:41Z
dc.date.available2023-09-11T15:59:41Z
dc.date.issued2023-07
dc.description.abstractHuman ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies or treatments that can lessen suffering, disability, and dependence in old age. In this review, we summarise the healthy ageing scores reported in the literature, with a focus on the past 5 years, and compare and contrast the variables employed. The use of approaches to determine biological age, molecular biomarkers, ageing trajectories, and multi-omics ageing scores are reviewed. We conclude that the ideal healthy ageing score is multisystemic and able to encompass all of the potential alterations associated with ageing. It should also be longitudinal and able to accurately predict ageing complications at an early stage in order to maximize the chances of successful early intervention.pt_PT
dc.description.sponsorshipALG-010145-FEDER-072586pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s10522-023-10041-2pt_PT
dc.identifier.issn1573-6768
dc.identifier.urihttp://hdl.handle.net/10400.1/19962
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHealthy ageingpt_PT
dc.subjectAgeing scorespt_PT
dc.subjectAgeing biomarkerspt_PT
dc.subjectBiological agept_PT
dc.titleMeasuring healthy ageing: current and future toolspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBiogerontologypt_PT
person.familyNameSilva
person.familyNameRajado
person.familyNameOleiro Esteves
person.familyNameVilhena Catarino Brito
person.familyNameApolónio
person.familyNameRoberto
person.familyNameBinnie
person.familyNamePombinho de Araújo
person.familyNameNóbrega
person.familyNameBragança
person.familyNameCastelo-Branco
person.givenNameNádia
person.givenNameAna Teresa
person.givenNameFilipa Alexandra
person.givenNameDavid
person.givenNameJoana
person.givenNameVânia
person.givenNameAlexandra
person.givenNameInês Maria
person.givenNameClévio
person.givenNameJosé
person.givenNamePedro
person.identifier1230353
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person.identifier.scopus-author-id10244362100
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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