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Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment

2022Journal article Restricted access
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dc.contributor.authorPes, Katia
dc.contributor.authorOrtiz-Delgado, Juan B.
dc.contributor.authorSarasquete, Carmen
dc.contributor.authorLaizé, Vincent
dc.contributor.authorFernández, Ignacio
dc.date.accessioned2022-09-20T13:24:16Z
dc.date.available2022-09-20T13:24:16Z
dc.date.issued2022
dc.description.abstractThe marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs - warfarin, dexamethasone and imidazole - on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alterations, antioxidant status, activity of antioxidant enzymes and expression of genes involved in the xenobiotic response (pxr, abcb1 and cyp1a), were evaluated. The results showed a time and drug-dependent effect. Warfarin exposure induced hemorrhages, hepatocyte vacuolar degeneration, and altered the activity of glutathione peroxidase (GPx) and the expression of all the studied genes. Dexamethasone exposure increased liver glycogen content, altered antioxidant status, GPx and superoxide dismutase activities, as well as abcb1 and cyp1a expression. Imidazole induced hepatocyte vacuolar degeneration and ballooning, and altered the antioxidant status and expression of the tested genes. The present work anticipates a deeper impact of pharmaceuticals on the aquatic environment than previously reported, thus underlining the urgent need for an integrated risk assessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.etap.2022.103822pt_PT
dc.identifier.eissn1872-7077
dc.identifier.urihttp://hdl.handle.net/10400.1/18267
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.subjectAquatic toxicologypt_PT
dc.subjectWarfarinpt_PT
dc.subjectDexamethasonept_PT
dc.subjectImidazolept_PT
dc.subjectVertebratespt_PT
dc.subjectFishpt_PT
dc.subjectGene expressionpt_PT
dc.subjectAntioxidant enzyme activitypt_PT
dc.titleShort-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.startPage103822pt_PT
oaire.citation.titleEnvironmental Toxicology and Pharmacologypt_PT
oaire.citation.volume90pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePes
person.familyNameLaizé
person.givenNameKatia
person.givenNameVincent
person.identifier.ciencia-id531A-DC47-297B
person.identifier.orcid0000-0002-0459-4622
person.identifier.orcid0000-0001-9565-9198
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id6602982778
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication21d44f44-a6ed-41fd-ad50-658b2df55097
relation.isAuthorOfPublicationb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
relation.isAuthorOfPublication.latestForDiscovery21d44f44-a6ed-41fd-ad50-658b2df55097
relation.isProjectOfPublicationfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f
relation.isProjectOfPublication.latestForDiscoveryfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f

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