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Reply to: Neurological outcome after cardiac arrest: cold and dark issues [editorial].
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We are thankful for the interest in our editorial.(1) We agree that the study population in Kim et al.(2) is different from that of Leão et al.(3), insofar as the first consisted of patients who had pre-hospital cardiorespiratory arrest, and the second consisted of patients with out-of-hospital and in-hospital cardiorespiratory arrest. However, neither study showed benefits to achieving the target hypothermia more quickly. In addition, the study by Leão et al. suggested a worse prognosis in patients who reached hypothermia more quickly.(3) As mentioned in the editorial, although the study had several limitations, there is a pathophysiological rationale for this finding.(4,5)