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Phenolic profile, cytotoxicity and in vitro antioxidant and enzyme inhibitory properties of the edible halophyte Sarcocornia fruticosa from southeastern Tunisia

2024-12Journal article Restricted
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dc.contributor.authorHarboub, Nesrine
dc.contributor.authorMighri, Hedi
dc.contributor.authorBennour, Naima
dc.contributor.authorGuerreiro Pereira, Catarina Alexandra
dc.contributor.authorFernandes, Eliana
dc.contributor.authorCastañeda-Loaiza, Viana
dc.contributor.authorCustódio, Luísa
dc.contributor.authorAbdellaoui, Raoudha
dc.contributor.authorAkrout, Ahmed
dc.date.accessioned2024-11-13T10:13:36Z
dc.date.available2024-11-13T10:13:36Z
dc.date.issued2024-12
dc.description.abstractThis work aims to boost the sustainable valorization of the edible halophyte Sarcocornia fruticosa (L.) A.J. Scott ( Amaranthaceae ) from Southern Tunisia by assessing its potential as a source of bioactive components. To achieve this, hydroethanolic extracts of S. fruticosa, , collected from two distinct Tunisian biomes (Zarzis: SFZ and Djerba: SFDJ), were profiled for total phenolic, flavonoid, and condensed tannin contents, as well as for individual phenolic composition by HPLC-ESI-MS. Then, the extracts were evaluated for in vitro antioxidant properties via complementary methods and for in vitro inhibition of enzymes related to Alzheimer's disease (acetylcholinesterase: AChE, and butyrylcholinesterase: BuChE), type 2 diabetes (alpha-glucosidase and alpha-amylase), and hyper- pigmentation and food oxidation (tyrosinase). Finally, they were assessed for acute in vitro toxicity. Our findings identified thirteen phenolic compounds, with rutin being the predominant compound and its content being nearly twice as high in SFZ than in SFDJ (1224.51 and 643.61 mg/kg DW, respectively). Salvianolic acid B was also reported for the first time in Sarcocornia genus. The extracts exhibited notable ferric reducing antioxidant power (FRAP), with SFZ displaying an effective median concentration (EC50) 50 ) value of 0.97 mg/mL. They also showed promising inhibitory effects on acetylcholinesterase (>40%) and tyrosinase (>50%), without any cytotoxicity. The Zarzis ecotype in particular displayed superior bioactive properties, making it an excellent candidate for future cultivation trials under saline conditions, with potentially valuable economic outcomes for the region. These findings highlight the potential of S. fruticosa as a source of functional ingredients with nutraceutical and therapeutic applications.eng
dc.description.sponsorshipDP-2022-1629; CEECIND/00425/2017
dc.identifier.doi10.1016/j.fbio.2024.105126
dc.identifier.issn2212-4292
dc.identifier.urihttp://hdl.handle.net/10400.1/26260
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relation.ispartofFood Bioscience
dc.rights.uriN/A
dc.subjectBioactive compounds
dc.subjectBioprospecting
dc.subjectHalophytes
dc.subjectSarcocornia fruticosa
dc.subjectSustainability
dc.titlePhenolic profile, cytotoxicity and in vitro antioxidant and enzyme inhibitory properties of the edible halophyte Sarcocornia fruticosa from southeastern Tunisiaeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.startPage105126
oaire.citation.titleFood Bioscience
oaire.citation.volume62
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameHarboub
person.familyNameGuerreiro Pereira
person.familyNameFernandes
person.familyNameCastañeda-Loaiza
person.familyNameCustódio
person.givenNameNesrine
person.givenNameCatarina Alexandra
person.givenNameEliana
person.givenNameViana
person.givenNameLuísa
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id2319-B2D8-AF48
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0009-0009-0335-5767
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4083-8353
person.identifier.orcid0000-0002-8839-1389
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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