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Parathyroid hormone-related protein in lower vertebrates

1998Journal article Restricted access
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dc.contributor.authorDanks, J. A.
dc.contributor.authorTrivett, M. K.
dc.contributor.authorPower, Deborah
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorMartin, T. J.
dc.contributor.authorIngleton, P. M.
dc.date.accessioned2014-05-14T08:29:14Z
dc.date.available2014-05-14T08:29:14Z
dc.date.issued1998
dc.date.updated2014-05-09T10:29:56Z
dc.description.abstract1. Parathyroid hormone-related protein (PTHrP) is an important mediator of humoral hypercalcaemia of malignancy in humans. Normal human subjects have very low levels of PTHrP in their circulation. 2. Parathyroid hormone-related protein has recently been demonstrated in high levels in the circulation and tissues of the sea bream and the dogfish, leading to the hypothesis that PTHrP may be a 'classical' hormone in fish. 3. Immunohistochemistry and in situ hybridization were performed to investigate the evolutionary history of PTHrP. Tissues were examined from a number of lower vertebrates, including lungfish, lamprey and several species of bony and cartilaginous fish. Parathyroid hormone-related protein was localized to the skin and to kidney tubules in all animals studied. In the developing lungfish, PTHrP was observed in the notochord, developing brain and skeletal muscle layers. These results suggest that PTHrP is of ancient origin and has a basic and fundamental function in vertebrates.por
dc.identifier.citationDanks, J. A.; Trivett, M. K.; Power, D. M.; Canario, A. V. M.; Martin, T. J.; Ingleton, P. M. Parathyroid hormone-related protein in lower vertebrates, Clinical and Experimental Pharmacology and Physiology, 25, 9, 750-752, 1998.por
dc.identifier.issn0305-1870
dc.identifier.otherAUT: DPO00386; ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3915
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectCalcium regulationpor
dc.subjectComparative endocrinologypor
dc.subjectOsmoregulationpor
dc.subjectParathyroid hormone-related proteinpor
dc.titleParathyroid hormone-related protein in lower vertebratespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage752por
oaire.citation.issue9por
oaire.citation.startPage750por
oaire.citation.titleClinical and Experimental Pharmacology and Physiologypor
oaire.citation.volume25por
person.familyNamePower
person.familyNameCanario
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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