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The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta‐analysis

2022Journal article Open access
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dc.contributor.authorMorvaridzadeh, Mojgan
dc.contributor.authorQorbani, Mostafa
dc.contributor.authorShokati Eshkiki, Zahra
dc.contributor.authorEstêvão, M. Dulce
dc.contributor.authorMohammadi Ganjaroudi, Negar
dc.contributor.authorToupchian, Omid
dc.contributor.authorAbdollahi, Shima
dc.contributor.authorPizarro, Ana Beatriz
dc.contributor.authorAbu‐Zaid, Ahmed
dc.contributor.authorZadro, Joshua R.
dc.contributor.authorHeshmati, Javad
dc.contributor.authorZiaei, Somayeh
dc.date.accessioned2023-02-01T10:42:17Z
dc.date.available2023-02-01T10:42:17Z
dc.date.issued2022
dc.description.abstractAlmond intake may be correlated with improvements in several cardiometabolic parameters, but its effects are controversial in the published literature, and it needs to be comprehensively summarized. We conducted a systematic search in several international electronic databases, including MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and until April 2021 to identify randomized controlled trials that examined the effects of almond consumption on cardiometabolic risk factors, inflammatory markers, and liver enzymes. Data were pooled using the random-effects model method and presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty-six eligible trials were analyzed (n = 1750 participants). Almond intake significantly decreased diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein (LDL), non-high-density lipoprotein (HDL), and very LDL (p < 0.05). The effects of almond intake on systolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, homeostatic model assessment of insulin resistance, C-peptide, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, C-reactive protein (CRP), hs-CRP (high sensitivity C-reactive protein), interleukin 6, tumor necrosis factor-alpha, ICAM (Intercellular Adhesion Molecule), VCAM (Vascular Cell Adhesion Molecule), homocysteine, HDL, ox-LDL, ApoA1, ApoB, and lipoprotien-a were not statistically significant (p > .05). The current body of evidence supports the ingestion of almonds for their beneficial lipid-lowering and antihypertensive effects. However, the effects of almonds on antiinflammatory markers, glycemic control, and hepatic enzymes should be further evaluated via performing more extensive randomized trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/ptr.7622pt_PT
dc.identifier.issn0951-418X
dc.identifier.urihttp://hdl.handle.net/10400.1/18980
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAlmondpt_PT
dc.subjectBlood lipidspt_PT
dc.subjectCardiometabolicpt_PT
dc.subjectGlycemic controlpt_PT
dc.subjectHepatic enzymespt_PT
dc.subjectInflammationpt_PT
dc.titleThe effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta‐analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4344pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage4325pt_PT
oaire.citation.titlePhytotherapy Researchpt_PT
oaire.citation.volume36pt_PT
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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