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LPS modulates the expression of iron-related immune genes in two Antarctic notothenoids

2020-02Journal article Open access
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dc.contributor.authorMartínez, Danixa Pamela
dc.contributor.authorSousa, Carmen
dc.contributor.authorOyarzún, Ricardo
dc.contributor.authorPontigo, Juan Pablo
dc.contributor.authorCanario, Adelino
dc.contributor.authorPower, Deborah
dc.contributor.authorVargas-Chacoff, Luis
dc.contributor.authorGuerreiro, Pedro
dc.date.accessioned2020-03-19T09:44:42Z
dc.date.available2020-03-19T09:44:42Z
dc.date.issued2020-02
dc.description.abstractThe non-specific immunity can induce iron deprivation as a defense mechanism against potential bacterial pathogens, but little information is available as to its role in Antarctic fish. In this study the response of iron metabolism related genes was evaluated in liver and head kidney of the Antarctic notothenoids Notothenia coriiceps and Notothenia rossii 7 days after lipopolysaccharide (LPS) injection. Average plasma Fe2+ concentration was unaffected by treatment in any of the species. The gene expression response to LPS varied between tissues and species, being stronger in N. coriiceps and more prominent in the head kidney than liver. The reaction to LPS was marked by increased individual variability in most genes analyzed, even when the change in expression was not statistically significant, suggesting different individual sensitivity and coping responses in these wild fish. We found that iron related genes had an attenuated and homogenous response to LPS but there was no detectable relationship between plasma Fe2+ and gene expression. However, overall in both tissues and species LPS exposure set a multilevel response that concur to promote intracellular accumulation of iron, an indication that Antarctic Notothenoids use innate nutritional immunity as a resistance mechanism against pathogens.pt_PT
dc.description.sponsorshipFCT-NSFC/0002/2016; PTDC/BIAANM/3484/2014pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fphys.2020.00102pt_PT
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10400.1/13614
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationCentre of Marine Sciences
dc.subjectNotothenia coriicepspt_PT
dc.subjectAntarctic fishpt_PT
dc.subjectNotothenia rossiipt_PT
dc.subjectNutritional immunitypt_PT
dc.subjectIron metabolismpt_PT
dc.titleLPS modulates the expression of iron-related immune genes in two Antarctic notothenoidspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014/PTDC%2FBIA-ANM%2F3484%2F2014/PT
oaire.citation.startPage102pt_PT
oaire.citation.titleFrontiers in Physiologypt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamProjetos de Investigação Científica e Desenvolvimento Tecnológico - 2014
person.familyNameVieira de Sousa
person.familyNameCanario
person.familyNamePower
person.familyNameGuerreiro da Costa Guerreiro
person.givenNameCármen Sofia
person.givenNameAdelino
person.givenNameDeborah Mary
person.givenNamePedro Miguel
person.identifier143624
person.identifierA-2539-2009
person.identifier.ciencia-idE511-2F93-F25D
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id5C13-965D-3148
person.identifier.orcid0000-0002-3483-1932
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0001-5371-7919
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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