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Biological characterization of Cynara cardunculus L. Methanolic extracts: antioxidant, anti-proliferative, anti-migratory and anti-angiogenic activities

2012-12-19Journal article Open access
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dc.contributor.authorVelez, Zélia
dc.contributor.authorCampinho, Marco António
dc.contributor.authorGuerra, Ângela R.
dc.contributor.authorGarcía, Laura
dc.contributor.authorRamos, Patricia
dc.contributor.authorGuerreiro, Olinda
dc.contributor.authorFelício, Laura
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorDuarte, Maria
dc.date.accessioned2022-10-17T14:22:04Z
dc.date.available2022-10-17T14:22:04Z
dc.date.issued2012-12-19
dc.date.updated2022-10-13T15:42:23Z
dc.description.abstract<i>Cynara cardunculus</i> (Cc) is a multipurpose species; beyond its use in southwestern European cuisine, it is also used for the production of solid biofuel, seed oil, biodiesel, paper pulp and cheese, as well as animal feed. In addition, Cc has a long tradition of use in folk medicine as a diuretic and liver protector. The value of this species as a source of bioactive compounds is known; however, pharmacological use would further increase its cultivation. The main goal of the current work was to evaluate the potential of Cc as source of anti-carcinogenic phytochemicals. Different methanolic extracts obtained from wild and cultivated plants were tested for antioxidant activity and effect on breast tumor cell viability. The most effective extract, both as antioxidant and inhibition of tumor cell viability, was tested for effects on angiogenesis and tumor cell migration capacity. All the extracts tested had high antioxidant activity; however, only green leaves and dry head extracts exhibit anti-proliferative activity. Green cultivated leaves (GCL) were the most effective extract both as antioxidant and inhibiting the proliferation of tumor cells; it is equally active inhibiting tumor cell migration and<i> in vivo</i> angiogenesis. GCL extract is an effective inhibitor of several key points in tumor development and thus a promising source of anti-carcinogenic phytochemicals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAgriculture 2 (4): 472-492 (2012)pt_PT
dc.identifier.doi10.3390/agriculture2040472pt_PT
dc.identifier.issn2077-0472
dc.identifier.urihttp://hdl.handle.net/10400.1/18402
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCynara cardunculuspt_PT
dc.subjectPhenolspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntitumorpt_PT
dc.subjectBreast cancerpt_PT
dc.titleBiological characterization of Cynara cardunculus L. Methanolic extracts: antioxidant, anti-proliferative, anti-migratory and anti-angiogenic activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage492pt_PT
oaire.citation.startPage472pt_PT
oaire.citation.titleAgriculturept_PT
person.familyNameVelez
person.familyNameCampinho
person.givenNameZélia
person.givenNameMarco António
person.identifier.ciencia-id4412-F95B-34A2
person.identifier.ciencia-id0E18-2560-6EC1
person.identifier.orcid0000-0003-2761-4048
person.identifier.orcid0000-0002-5238-0506
person.identifier.ridM-5283-2013
person.identifier.ridD-8833-2013
person.identifier.scopus-author-id16176444400
person.identifier.scopus-author-id8938999600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3292b0fd-8d08-4512-b512-a04b31a7926a
relation.isAuthorOfPublicationf8e8c466-6a6f-4ccf-b96d-34565fe53b6c
relation.isAuthorOfPublication.latestForDiscovery3292b0fd-8d08-4512-b512-a04b31a7926a

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