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Cadmium and vanadate oligomers effects on methaemoglobin reductase activity from Lusitanian toadfish: in vivo and in vitro studies

dc.contributor.authorAureliano, M.
dc.date.accessioned2014-07-23T12:06:24Z
dc.date.available2014-07-23T12:06:24Z
dc.date.issued2003
dc.description.abstractCadmium and two vanadate solutions as ‘metavanadate’ (containing ortho and metavanadate species) and ‘decavanadate’ (containing decameric species) (5 mM) were injected intraperitoneously in Halobatrachus didactylus (Lusitanian toadfish), in order to evaluate the effects of cadmium and oligomeric vanadate species on methaemoglobin reductase activity from fish red blood cells. Following short-term exposure (1 and 7 days), different changes were observed on enzyme activity. After 7 days of exposure, ‘metavanadate’ increased methaemoglobin reductase activity by 67% (P,0.05), whereas, minor effects were observed on enzymatic activity upon cadmium and ‘decavanadate’ administration. However, in vitro studies indicate that decameric vanadate, in concentrations as low as 50mM, besides strongly inhibiting methaemoglobin reductase activity, promotes haemoglobin oxidation to methaemoglobin. Although decameric vanadate species showed to be unstable in the different media used in this work, the rate of decameric vanadate deoligomerization is in general slow enough, making it possible to study its effects. It is concluded that the increase in H.didactylus methaemoglobin reductase activity is more pronounced upon exposition to ‘metavanadate’ than to cadmium and decameric species. Moreover, only decameric vanadate species promoted haemoglobin oxidation, suggesting that vanadate speciation is important to evaluate in vivo and in vitro effects on methaemoglobin reductase activity.por
dc.identifier.issn0162-0134
dc.identifier.otherAUT: MAA01296
dc.identifier.urihttp://hdl.handle.net/10400.1/4810
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier
dc.subjectVanadatepor
dc.subjectMethaemoglobin reductasepor
dc.subjectCadmiumpor
dc.titleCadmium and vanadate oligomers effects on methaemoglobin reductase activity from Lusitanian toadfish: in vivo and in vitro studiespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage290por
oaire.citation.startPage285por
oaire.citation.titleJournal Inorganic Biochemistrypor
oaire.citation.volume94por
person.familyNameAureliano
person.givenNameManuel
person.identifier584146
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id6603412860
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationbb413661-7edd-4b57-8338-33889cfd05db
relation.isAuthorOfPublication.latestForDiscoverybb413661-7edd-4b57-8338-33889cfd05db

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