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Oestrogen, an evolutionary conserved regulator of T cell differentiation and immune tolerance in jawed vertebrates?

2018Journal article Open Access
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dc.contributor.authorPaiola, Matthieu
dc.contributor.authorKnigge, Thomas
dc.contributor.authorDuflot, Aurélie
dc.contributor.authorPinto, Patricia IS
dc.contributor.authorFarcy, Emilie
dc.contributor.authorMonsinjon, Tiphaine
dc.date.accessioned2020-03-23T14:22:15Z
dc.date.available2020-03-23T14:22:15Z
dc.date.issued2018
dc.description.abstractIn teleosts, as in mammals, the immune system is tightly regulated by sexual steroid hormones, such as oestrogens. We investigated the effects of 17β-oestradiol on the expression of several genes related to T cell development and resulting T cell subpopulations in sea bass, Dicentrarchus labrax, for a primary lymphoid organ, the thymus, and two secondary lymphoid organs, the head-kidney and the spleen. In parallel, the oxidative burst capacity was assessed in leucocytes of the secondary lymphoid organs. Apoptosis- and proliferation-related genes, indicative of B and T cell clonal selection and lymphoid progenitor activity, were not affected by elevated oestrogen-levels. Sex-related oestrogen-responsiveness in T cell and antigen-presenting cell markers was observed, the expression of which was differentially induced by oestrogen-exposure in the three lymphoid organs. Remarkably, in the spleen, oestrogen increased regulatory T cell-related gene expression was associated with a decrease in oxidative burst capacity. To the best of our knowledge, this study indicates for the first time that physiological levels of oestrogen are likely to promote immune tolerance by modulating thymic function (i.e., T cell development and output) and peripheral T cells in teleosts, similar to previously reported oestrogenic effects in mammals.pt_PT
dc.description.sponsorshipCCMAR/Multi/04326/2013; ANRfinanced project ETaT(ANR-15-CE32-0014); FR CNRS 3730 SCALE scholarshippt_PT
dc.description.sponsorshipANR-15-CE32-001; R CNRS 3730
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.dci.2018.01.013pt_PT
dc.identifier.issn0145-305X
dc.identifier.urihttp://hdl.handle.net/10400.1/13641
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationE2SCALE: Scaling-down estrogenic responses in fish
dc.relationCentre of Marine Sciences
dc.subjectAnimalspt_PT
dc.subjectAntigen-presenting cellspt_PT
dc.subjectB-Lymphocytespt_PT
dc.subjectBasspt_PT
dc.subjectCell differentiationpt_PT
dc.subjectClonal deletionpt_PT
dc.subjectEstrogenspt_PT
dc.subjectEvolutionpt_PT
dc.subjectFemalept_PT
dc.subjectImmune tolerancept_PT
dc.subjectLymphocyte activationpt_PT
dc.subjectMalept_PT
dc.subjectSexpt_PT
dc.subjectT-lymphocyte subsetspt_PT
dc.subjectT-lymphocytespt_PT
dc.subjectGamma-delta T cellpt_PT
dc.subjectHead-kidneypt_PT
dc.subjectRegulatory T cellpt_PT
dc.subjectSpleenpt_PT
dc.subjectTeleostpt_PT
dc.subjectThymuspt_PT
dc.titleOestrogen, an evolutionary conserved regulator of T cell differentiation and immune tolerance in jawed vertebrates?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleE2SCALE: Scaling-down estrogenic responses in fish
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAAG-GLO%2F4003%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F84033%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2013/PT
oaire.citation.endPage61pt_PT
oaire.citation.startPage48pt_PT
oaire.citation.titleDevelopmental and Comparative Immunologypt_PT
oaire.citation.volume84pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePinto
person.givenNamePatricia IS
person.identifier643457
person.identifier.ciencia-idE51D-5CCB-B1C6
person.identifier.orcid0000-0001-7854-3898
person.identifier.ridM-3817-2013
person.identifier.scopus-author-id10240774300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery64bc526e-5281-44e5-91eb-5743436109f9
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