Publication
The ves hypothesis and protein misfolding
| dc.contributor.author | Cruzeiro, Leonor | |
| dc.date.accessioned | 2014-03-03T15:41:55Z | |
| dc.date.available | 2014-03-03T15:41:55Z | |
| dc.date.issued | 2011 | |
| dc.date.updated | 2014-02-27T16:40:28Z | |
| dc.description.abstract | Proteins function by changing conformation. These conformational changes, which involve the concerted motion of a large number of atoms are classical events but, in many cases, the triggers are quantum mechani- cal events such as chemical reactions. Here the initial quantum states after the chemical reaction are assumed to be vibrational excited states, something that has been designated as the VES hypothesis. While the dynamics under classical force fields fail to explain the relatively lower structural stability of the proteins associated with misfolding diseases, the application of the VES hy- pothesis to two cases can provide a new explanation for this phenomenon. This explanation relies on the transfer of vibrational energy from water molecules to proteins, a process whose viability is also examined. | por |
| dc.identifier.citation | Cruzeiro, L.The ves hypothesis and protein misfolding, Discrete and Continuous Dynamical Systems - Series S, 4, 5, 1033-10, 2011. | por |
| dc.identifier.doi | http://dx.doi.org/10.3934/dcdss.2011.4.1033 | |
| dc.identifier.issn | 1937-1632 | |
| dc.identifier.other | AUT: LHA01632; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/3551 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Institute of Mathematical Sciences | por |
| dc.relation.publisherversion | http://www.aimsciences.org/journals/displayArticles.jsp?paperID=5760 | por |
| dc.subject | Davydov/Scott model | por |
| dc.subject | Neurodegenerative diseases, | por |
| dc.subject | Ice worm | por |
| dc.title | The ves hypothesis and protein misfolding | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1046 | por |
| oaire.citation.issue | 5 | |
| oaire.citation.startPage | 1033 | por |
| oaire.citation.title | Discrete and Continuous Dynamical Systems - Series S | por |
| oaire.citation.volume | 4 | por |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |