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Characterization of the knee joint phenotype in the Portuguese population

2024-04-29Journal article Open Access
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dc.contributor.authorSeica, Emanuel Cortesao de
dc.contributor.authorArmada, Lucas
dc.contributor.authorMarreiros, Ana
dc.contributor.authorde Almeida Fontes, Ana Paula
dc.contributor.authorCarvalho, Maria Miguel
dc.contributor.authorSousa, João Paulo
dc.date.accessioned2024-11-11T14:45:50Z
dc.date.available2024-11-11T14:45:50Z
dc.date.issued2024-04-29en_US
dc.date.updated2024-11-10T17:25:17Z
dc.description.abstractBackground: Neutral constitutional alignment and neutral joint line obliquity has been the standard alignment strategy for total knee arthroplasty. This one-for-all measure may negatively impact gait pattern and knee biomechanics. Novel alignment strategies surged, considering the variability in phenotypes found across the literature, as different populations may present different phenotype distributions. The Portuguese population has a distinct genetic origin, with no phenotype distribution data. Our objective was to characterise the population’s knee morphology, searching and analysing adjacent joint osteoarthrosis, and calculating the pre-disease coronal alignment. Methods: A retrospective cohort study was conducted. Full-length X-rays performed between 2016-2023 were analysed. Five alignment parameters were measured (LDFA, MPTA, JLCA, TJLA, HKA), and two parameters were calculated (aHKA, JLO). Knees were classified according to the CPAK classification. Results: For the arthritic cohort, CPAK-I (23%) II (20%) were most common, aHKA increases as KL increases (r=0.8352; p<0.001). For the healthy, Type-II (42%) and Type-I (15%) were most common. For paediatric, Type-II (43%) and Type-V (21%) were most common. CPAK Types-VII/VIII/IX were rare. Differences between genders for healthy and arthritic cohorts were statistically significant. The arthritic had higher prevalence of adjacent joint osteoarthritis. Conclusions: The Portuguese population presents a similar knee phenotype comparing with other populations, some differences have been found regarding the Asian continent. The most common phenotype was a neutral alignment if either healthy or paediatric, or a varus alignment if knee OA. Coronal alignment may not have a major impact in the prevalence of ankle and hip osteoarthritis; however, higher prevalence is observed in patients with knee OA.eng
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.18203/issn.2455-4510.intjresorthop20241102en_US
dc.identifier.issn2455-4510en_US
dc.identifier.slugcv-prod-4192332
dc.identifier.urihttp://hdl.handle.net/10400.1/26246
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMedip Academy
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCPAK
dc.subjectKnee phenotype
dc.subjectPortuguese population
dc.subjectPre-disease coronal alignment
dc.subjectOsteoarthritis
dc.titleCharacterization of the knee joint phenotype in the Portuguese populationeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage528
oaire.citation.issue3en_US
oaire.citation.startPage520
oaire.citation.titleInternational Journal of Research in Orthopaedicsen_US
oaire.citation.volume10en_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMarreiros
person.familyNamede Almeida Fontes
person.givenNameAna
person.givenNameAna Paula
person.identifier.ciencia-id9A12-9450-7051
person.identifier.ciencia-id6E12-B4BA-87AF
person.identifier.orcid0000-0001-9410-4772
person.identifier.orcid0000-0002-4431-5229
person.identifier.scopus-author-id57194785077
rcaap.cv.cienciaid6E12-B4BA-87AF | Ana Paula de Almeida Fontes
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationc0a8e5da-26ae-42a8-ab04-fa4df4356375
relation.isAuthorOfPublication00fe72a3-c82a-4726-bd5d-efeb7fb59650
relation.isAuthorOfPublication.latestForDiscovery00fe72a3-c82a-4726-bd5d-efeb7fb59650

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