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Duplicated receptors for VIP and PACAP VPAC 1 R and PAC 1 R in a teleost fish, Fugu rubripes

2004Journal article Restricted access
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dc.contributor.authorCardoso, João CR
dc.contributor.authorPower, Deborah
dc.contributor.authorElgar, Greg
dc.contributor.authorClark, M. S.
dc.date.accessioned2014-10-23T10:06:07Z
dc.date.available2014-10-23T10:06:07Z
dc.date.issued2004
dc.description.abstractTwo principal groups of receptors orthologous with human PAC1R and VPAC1R and were identified and characterised at the genomic level in the teleost fish Fugu rubripes. An additional group orthologous with VPAC2R was also identified and partially characterised. In Fugu, gene duplication of each of the PAC1Rs, VPAC1Rs and VPAC2Rs appears to have occurred. The topology of the tree surrounding the Fugu duplications and other isolated piscine sequences indicates that the duplication events for these six genes clearly preceded the speciation event leading to the Cypriniformes and Tetraodontiformes and is probably teleost-specific. Overall, the combined pattern of gene expression for each pair of duplicated genes mirrored the expression in other vertebrates. However, within each pair of duplicates further specialisation had occurred, with each demonstrating differential tissue distribution profiles suggesting they that may be responsible for the divergent action of the ligands, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP). The Fugu VPAC1R gene regions showed conserved synteny with human chromosome 3p21·3 and also C. elegans chromosome X, indicating that the putative ancestral human chromosome 3 region may be equivalent to chromosome X in Caenorhabditis elegans.por
dc.description.sponsorshipThis work was supported by an MRC grant to MSC and GE and an FCT pluriannual grant to CCMAR, Portugal. DMP was in receipt of a sabbatical grant (BLS58, FCT, Portugal). JCRC was funded by FCT, Portugal (grant, BD/19925/ 99).por
dc.identifier.citationJ C R Cardoso, D M Power, G Elgar and M S Clark, "Duplicated receptors for VIP and PACAP (VPAC(1)R and PAC(1)R) in a teleost fish, Fugu rubripes" in Journal of Molecular Endocrinology (2004) 33, 411–428.por
dc.identifier.doihttp://dx.doi.org/10.1677/jme.1.01575
dc.identifier.issn0952-5041
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5423
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociety for Endocrinologypor
dc.titleDuplicated receptors for VIP and PACAP VPAC 1 R and PAC 1 R in a teleost fish, Fugu rubripespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage428por
oaire.citation.startPage411por
oaire.citation.titleJournal of Molecular Endocrinologypor
oaire.citation.volume33por
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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