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Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages

2016-07Journal article Restricted access
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dc.contributor.authorCardoso, João CR
dc.contributor.authorBergqvist, Christina A.
dc.contributor.authorFélix, Rute C.
dc.contributor.authorLarhammar, Dan
dc.date.accessioned2017-04-07T15:56:24Z
dc.date.available2017-04-07T15:56:24Z
dc.date.issued2016-07
dc.description.abstractThe evolution of the peptide family consisting of corticotropin-releasing hormone ( CRH) and the three urocortins ( UCN1-3) has been puzzling due to uneven evolutionary rates. Distinct gene duplication scenarios have been proposed in relation to the two basal rounds of vertebrate genome doubling ( 2R) and the teleost fish-specific genome doubling ( 3R). By analyses of sequences and chromosomal regions, including many neighboring gene families, we show here that the vertebrate progenitor had two peptide genes that served as the founders of separate subfamilies. Then, 2R resulted in a total of five members: one subfamily consists of CRH1, CRH2, and UCN1. The other subfamily contains UCN2 and UCN3. All five peptide genes are present in the slowly evolving genomes of the coelacanth Latimeria chalumnae ( a lobe-finned fish), the spotted gar Lepisosteus oculatus ( a basal ray-finned fish), and the elephant shark Callorhinchus milii ( a cartilaginous fish). The CRH2 gene has been lost independently in placental mammals and in teleost fish, but is present in birds ( except chicken), anole lizard, and the nonplacental mammals platypus and opossum. Teleost 3R resulted in an additional surviving duplicate only for crh1 in some teleosts including zebrafish ( crh1a and crh1b). We have previously reported that the two vertebrate CRH/UCN receptors arose in 2R and that CRHR1 was duplicated in 3R. Thus, we can now conclude that this peptide-receptor system was quite complex in the ancestor of the jawed vertebrates with five CRH/UCN peptides and two receptors, and that crh and crhr1 were duplicated in the teleost fish tetraploidization.
dc.identifier.doi10.1530/JME-16-0051
dc.identifier.issn0952-5041
dc.identifier.urihttp://hdl.handle.net/10400.1/9404
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBioScientifica
dc.relation.isbasedonWOS:000380717500014
dc.subjectCRH/UCN
dc.subjectPhylogeny
dc.subjectGene duplication
dc.subjectSynteny
dc.titleCorticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F89811%2F2012/PT
oaire.citation.endPage86
oaire.citation.issue1
oaire.citation.startPage73
oaire.citation.titleJournal of Molecular Endocrinology
oaire.citation.volume57
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameCardoso
person.givenNameJoão
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.orcid0000-0001-7890-0170
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublication.latestForDiscovery1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isProjectOfPublication868b4818-3efa-4edb-9202-c464d64fd38f
relation.isProjectOfPublication6ca85b9c-91db-48e5-a1f5-29e42ee8d786
relation.isProjectOfPublication.latestForDiscovery868b4818-3efa-4edb-9202-c464d64fd38f

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