Publication
Aflatoxicosis Dysregulates the Physiological Responses to Crowding Densities in the Marine Teleost Gilthead Seabream (Sparus aurata)
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Advisor(s)
Abstract(s)
Several studies in fish have shown that aflatoxin B1 (AFB1) causes a disparity of speciesdependent physiological disorders without compromising survival. We studied the effect of dietary
administration of AFB1 (2 mg AFB1 kg−1 diet) in gilthead seabream (Sparus aurata) juveniles in
combination with a challenge by stocking density (4 vs. 40 g L−1
). The experimental period duration
was ten days, and the diet with AFB1 was administered to the fish for 85 days prior to the stocking
density challenge. Our results indicated an alteration in the carbohydrate and lipid metabolites
mobilization in the AFB1 fed group, which was intensified at high stocking density (HSD). The CT
group at HSD increased plasma cortisol levels, as expected, whereas the AFB1-HSD group did not.
The star mRNA expression, an enzyme involved in cortisol synthesis in the head kidney, presented
a ninefold increase in the AFB1 group at low stocking density (LSD) compared to the CT-LSD
group. Adenohypophyseal gh mRNA expression increased in the AFB1-HSD but not in the CT-HSD
group. Overall, these results confirmed that chronic AFB1 dietary exposure alters the adequate
endocrinological physiological cascade response in S. aurata, compromising the expected stress
response to an additional stressor, such as overcrowding.
Description
Keywords
Sparidae Stress Aquaculture Stocking density Endocrine-related genes Energetic metabolism Mycotoxin
Citation
Animals 11 (3): 753 (2021)
Publisher
MDPI