Repository logo
 
Publication

Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase

2014-06Journal article Restricted
Simple item page
dc.contributor.authorCavaco, S.
dc.contributor.authorWilliamson, M. K.
dc.contributor.authorRosa, Joana
dc.contributor.authorRoberto, Vania Palma
dc.contributor.authorCordeiro, O.
dc.contributor.authorPrice, P. A.
dc.contributor.authorCancela, Leonor
dc.contributor.authorLaizé, Vincent
dc.contributor.authorSimes, D
dc.date.accessioned2014-06-12T10:39:20Z
dc.date.available2014-06-12T10:39:20Z
dc.date.issued2014-06
dc.date.updated2014-06-03T09:34:56Z
dc.description.abstractThe occurrence of a second osteocalcin (OC2) has been reported in teleost fish, where it coexists with OC1 in some species. While it has been proposed that OC2 gene originated from OC1 through the fish whole-genome duplication event, little information is available on its molecular function and physiological role. The present study brings biological data supporting the presence of OC2 in the mineral phase of teleost fish bone and its association with the mineral phase together with OC1. The occurrence of OC2 forms with different levels of phosphorylation or c-carboxylation, and with amino acid substitutions was observed. Comparative analysis of mature peptide sequences revealed the high conservation existing between OC1 and OC2, in particular within the core c-carboxyglutamic acid domain, and suggests that both protein forms may have the same function, i.e., binding of calcium ions or hydroxyapatite crystals.por
dc.identifier.citationCavaco, Sofia; Williamson, Matthew K.; Rosa, Joana; Roberto, Vânia; Cordeiro, Odete; Price, Paul A.; Leonor Cancela, M.; Laizé, Vincent; Simes, Dina C.Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase, Fish Physiology and Biochemistry, 40, 3, 731-738, 2014.por
dc.identifier.doihttp://dx.doi.org/10.1007/s10695-013-9880-9
dc.identifier.issn0920-1742
dc.identifier.otherAUT: LCA00739; DSI00813
dc.identifier.urihttp://hdl.handle.net/10400.1/4276
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relation.publisherversionhttp://download.springer.com/static/pdf/162/art%253A10.1007%252Fs10695-013-9880-9.pdf?auth66=1402741876_4ee4277a0f91c6ba45585c8592515d3b&ext=.pdfpor
dc.subjectVitamin K-dependent proteinspor
dc.subjectProtein purificationpor
dc.subjectBone tissuepor
dc.subjectTeleost fishpor
dc.subjectOsteocalcinpor
dc.titleTeleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phasepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage738por
oaire.citation.issue3por
oaire.citation.startPage731por
oaire.citation.titleFish Physiology and Biochemistrypor
oaire.citation.volume40por
person.familyNameRosa
person.familyNameRoberto
person.familyNameCancela
person.familyNameLaizé
person.familyNameSimes
person.givenNameJoana
person.givenNameVânia
person.givenNameM. Leonor
person.givenNameVincent
person.givenNameDina
person.identifier1230353
person.identifier.ciencia-id0B18-8AEC-875C
person.identifier.ciencia-id681E-40B7-331F
person.identifier.orcid0000-0001-7947-2681
person.identifier.orcid0000-0002-8134-4045
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0002-5145-4753
person.identifier.ridB-4463-2008
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id36505067900
person.identifier.scopus-author-id27467657800
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id7201884723
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication181f1017-5086-40dc-9edc-a289aaa2d263
relation.isAuthorOfPublicationc730a868-0e9f-43e4-a354-10130b30b764
relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
relation.isAuthorOfPublicationb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
relation.isAuthorOfPublication31bac96d-1d01-4b8f-8f2b-9da4be31ea41
relation.isAuthorOfPublication.latestForDiscovery181f1017-5086-40dc-9edc-a289aaa2d263

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase.pdf
Size:
1.89 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)