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Calcitonin: characterisation and expression in a teleost fish, Fugu rubripes

2002-04Journal article Open Access
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dc.contributor.authorClark, Melody
dc.contributor.authorBendell, L
dc.contributor.authorPower, DM
dc.contributor.authorWarner, S
dc.contributor.authorElgar, Greg
dc.contributor.authorIngleton, P. M.
dc.date.accessioned2018-12-07T14:52:32Z
dc.date.available2018-12-07T14:52:32Z
dc.date.issued2002-04
dc.description.abstractThe present report describes the structure and expression of the calcitonin gene in Fugu rubripes. It is composed of 4 exons and 3 introns. Splicing of exons 1, 2 and 3 generates the calcitonin pre-proprotein, while splicing of exons 1, 2 and 4 generates calcitonin gene-related protein (CGRP). Exons 1 and 2 encoding the signal sequence and the N-terminal peptide are common in both the gene products and this gene organisation has been conserved in human, rat, chicken and salmon. The gene environment around calcitonin in Fugu has been poorly conserved when compared with human, apart from a small gene cluster. The calcitonin gene in Fugu has a widespread tissue distribution but it is most highly expressed in the brain. The abundance of gene expression in the ultimobranchial gland and the pituitary indicates that these are important sites of production and that the peptide is probably secreted into the circulation and/or acts as a paracrine or autocrine controlling factor. Whilst the function of calcitonin in fish is still largely unknown, the distribution described here suggests that one of the potential functions may be as a neuropeptide.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1677/jme.0.0280111
dc.identifier.issn0952-5041
dc.identifier.urihttp://hdl.handle.net/10400.1/11111
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSociety for Endocrinology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHormone-related protein
dc.subjectSalmon-calcitonin
dc.subjectTakifugu niphobles
dc.subjectGene-expression
dc.subjectPuffer fish
dc.subjectBrown trout
dc.subjectSequence
dc.subjectRna
dc.subjectPituitary
dc.subjectDatabase
dc.titleCalcitonin: characterisation and expression in a teleost fish, Fugu rubripes
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage123
oaire.citation.issue2
oaire.citation.startPage111
oaire.citation.titleJournal of Molecular Endocrinology
oaire.citation.volume28
person.familyNameClark
person.familyNamePower
person.familyNameElgar
person.givenNameMelody
person.givenNameDeborah Mary
person.givenNameGreg
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-3442-3824
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0001-7323-1596
person.identifier.ridD-7371-2014
person.identifier.scopus-author-id7101806760
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationfee7f1e6-4d82-4a26-b123-97e0f9b38495
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublicationadc4b057-4dbc-4283-914d-7b0459f8c24c
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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