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Histopathological assessment and inflammatory response in the digestive gland of marine mussel Mytilus galloprovincialis exposed to cadmium-based quantum dots

2016-08Journal article Restricted access
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dc.contributor.authorRocha, Thiago Lopes
dc.contributor.authorSaboia-Morais, Simone Maria Teixeira
dc.contributor.authorBebianno, Maria
dc.date.accessioned2017-04-07T15:56:16Z
dc.date.available2017-04-07T15:56:16Z
dc.date.issued2016-08
dc.description.abstractAlthough tissue-level biomarkers have been widely applied in environmental toxicology studies, the knowledge using this approach in marine invertebrates exposed to engineered nanomaterials (ENMs) remains limited. This study investigated histopathological alterations and inflammatory responses induced by Cd-based quantum dots (QDs), in comparison with their dissolved counterparts, in the marine mussel Mytilus galloprovincialis. Mussels were exposed to CdTe QDs and dissolved Cd at the same concentration (10 mu g Cd L-1) for 14 days and a total of 15 histopathological alterations and 17 histomorphometric parameters were analysed in the digestive gland along with the determination of histopathological condition indices (I-h). A multivariate analysis showed that the mussel response to QDs was more related to exposure time, inflammatory conditions (frequency of haemocytic infiltration and granulocytomas) and changes of cell-type composition (especially the rate between basophilic and digestive cells) when compared to dissolved Cd, while the response to dissolved Cd was associated with histomorphometric parameters of the epithelium and lumen of digestive tubules and increase of the atrophic tubule frequency. Both Cd forms induced higher I-h compared to unexposed mussels indicating a significant decrease in the health status of digestive gland in a Cd form and time-dependent pattern. Results indicate that the multiparametric tissue-level biomarkers in the digestive gland provide a suitable approach to assess the ecotoxicity and mode of action of metal-based ENMs in marine bivalves. (C) 2016 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScience Without Borders Program (239524/2012-8)
dc.identifier.doi10.1016/j.aquatox.2016.06.003
dc.identifier.issn0166-445X
dc.identifier.otherAUT: MBE00379;
dc.identifier.urihttp://hdl.handle.net/10400.1/9365
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMembrane technology to treat effluents with metal nanoparticles
dc.relation.isbasedonWOS:000381529700030
dc.titleHistopathological assessment and inflammatory response in the digestive gland of marine mussel Mytilus galloprovincialis exposed to cadmium-based quantum dots
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMembrane technology to treat effluents with metal nanoparticles
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAAC-AMB%2F121650%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FECM%2F102244%2F2008/PT
oaire.citation.endPage315
oaire.citation.startPage306
oaire.citation.titleAquatic Toxicology
oaire.citation.volume177
oaire.fundingStreamCOMPETE
oaire.fundingStream3599-PPCDT
person.familyNameBebianno
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isProjectOfPublication4a1b04fa-ed2d-4fa6-ad48-19c74272bcc0
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